Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 13/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25436458 | 0.85 | SPPL2A (0.40) | SPPL2A | |
| SCHEMBL25408832 | 0.76 | ANPEP (0.44) | SPPL2A | |
| SCHEMBL25410229 | 0.76 | ANPEP (0.44) | SPPL2A | |
| SCHEMBL26855727 | 0.73 | SPPL2A (0.53) | SPPL2A | |
| SCHEMBL1263616 | 0.72 | CES1 (0.45) | KMT2AKDM1AKEAP1 | |
| SCHEMBL25408370 | 0.70 | SPPL2A (0.60) | SPPL2AKMT2A | |
| SCHEMBL25407546 | 0.70 | SPPL2A (0.60) | SPPL2AKMT2A | |
| SCHEMBL30617078 | 0.69 | KMT2A (0.44) | SPPL2AKMT2ALMNA | |
| SCHEMBL25408472 | 0.69 | KMT2A (0.44) | SPPL2AKMT2ALMNA | |
| SCHEMBL26847744 | 0.69 | KMT2A (0.44) | SPPL2AKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250263416-A1 | SPPL2a INHIBITORS | INCYTE CORPORATION | 2025-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250263416-A1 | SPPL2a INHIBITORS | SPPL2A, SPPL2B, BACE1 | SPPL2A 1/4885KMT2A 1935/4885KDM1A 3577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.