SCHEMBL31691450

SCHEMBL31691450

C=Cc1cc(C(=O)NS(=O)(=O)c2nc(C(C)(C)C)ccc2OC)ccc1Cn1cccn1

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ KAT7 O95251 13/20 0.40
▸ KAT6A Q92794 13/20 0.40
▸ KLKB1 P03952 2/20 0.37
▸ KAT6B Q8WYB5 9/20 0.36
▸ KAT5 Q92993 6/20 0.36
▸ KAT8 Q9H7Z6 6/20 0.36
▸ HDAC1 Q13547 1/20 0.35
▸ HDAC6 Q9UBN7 1/20 0.35
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ NPSR1 Q6W5P4 2/20 0.34
▸ MAPT P10636 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31691398 0.90 KAT7 (0.43) KAT7KAT6AKLKB1KAT6BKAT5
SCHEMBL31691319 0.90 KAT7 (0.44) KAT7KAT6AKLKB1KAT6BKAT5
SCHEMBL31691454 0.88 KAT7 (0.43) KAT7KAT6AKLKB1KAT6BKAT5
SCHEMBL31691513 0.88 KAT7 (0.41) KAT7KAT6AKLKB1KAT6BKAT5
SCHEMBL31691344 0.88 KAT7 (0.42) KAT7KAT6AKLKB1KAT6BKAT5
SCHEMBL31691479 0.87 KAT7 (0.41) KAT7KAT6AKLKB1KAT6BKAT5
SCHEMBL31691452 0.86 KAT7 (0.40) KAT7KAT6AKLKB1KAT6BKAT5
SCHEMBL31691468 0.86 KAT7 (0.39) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL31691258 0.85 KAT7 (0.45) KAT7KAT6AKLKB1KAT6BKAT5
SCHEMBL31691348 0.85 KAT7 (0.41) KAT7KAT6AKLKB1KAT6BKAT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304535-A1 KAT6 Inhibitors BEIGENE SWITZERLAND GMBH (CH) 2025-10-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304535-A1 KAT6 Inhibitors KAT6A, KAT6B, KAT2A KAT7 4/4885KAT6A 1/4885KLKB1 2673/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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