Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 18/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | GPR183 | P32249 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13528202 | 0.91 | TACR1 (0.49) | TACR1NR3C1CYP3A4FPR1TACR3 | |
| SCHEMBL3179950 | 0.88 | TACR1 (0.50) | TACR1 | |
| SCHEMBL13528124 | 0.88 | TACR1 (0.50) | TACR1 | |
| SCHEMBL13953505 | 0.88 | TACR1 (0.50) | TACR1 | |
| SCHEMBL13528654 | 0.88 | TACR1 (0.50) | TACR1 | |
| SCHEMBL3172265 | 0.88 | TACR1 (0.50) | TACR1 | |
| SCHEMBL13528647 | 0.88 | TACR1 (0.50) | TACR1 | |
| SCHEMBL13528193 | 0.87 | TACR1 (0.49) | TACR1NR3C1CYP3A4FPR1TACR3 | |
| SCHEMBL3164796 | 0.87 | TACR1 (0.47) | TACR1NR3C1CYP3A4FPR1TACR3 | |
| SCHEMBL3164597 | 0.85 | TACR1 (0.55) | TACR1NR3C1CYP3A4FPR1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652058-B2 | Octahydropyrano[3,4-C]pyrrole tachykinin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-01-26 | — | — | US | disclosed |
| US-7652058-B2 | Octahydropyrano[3,4-C]pyrrole tachykinin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-01-26 | — | — | US | disclosed |
| US-7652058-B2 | Octahydropyrano[3,4-C]pyrrole tachykinin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-01-26 | — | — | US | disclosed |
| US-20090048248-A1 | Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2009-02-19 | — | — | US | disclosed |
| US-20080108689-A1 | Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2008-05-08 | — | — | US | disclosed |
| US-20080108689-A1 | Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2008-05-08 | — | — | US | disclosed |
| US-20080108689-A1 | Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108689-A1 | Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists | TACR1, TACR2, NPSR1 | TACR1 1/4885NR3C1 781/4885CYP3A4 2670/4885 |
| US-20090048248-A1 | Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists | TACR1, TACR2, NPSR1 | TACR1 1/4885NR3C1 824/4885CYP3A4 2733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.