Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | PDE8A | O60658 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31706638 | 1.00 | PIK3CA (0.50) | PIK3CAPIK3CDDYRK1AIRAK4IKBKE | |
| SCHEMBL31704510 | 0.86 | PIK3CD (0.52) | PIK3CAPIK3CDIKBKETBK1KMO | |
| SCHEMBL31705259 | 0.81 | PIK3CD (0.51) | PIK3CAPIK3CDDYRK1AIRAK4PDE10A | |
| SCHEMBL31704875 | 0.81 | PIK3CD (0.51) | PIK3CAPIK3CDDYRK1AIRAK4PDE10A | |
| Lithium Ion SCHEMBL31706664 | 0.77 | PIK3CA (0.46) | PIK3CAPIK3CDDYRK1AIRAK4IKBKE | |
| Lithium Ion SCHEMBL31704606 | 0.75 | PIK3CD (0.44) | PIK3CAPIK3CDDYRK1AIKBKETBK1 | |
| Lithium Ion SCHEMBL31705859 | 0.75 | PIK3CD (0.44) | PIK3CAPIK3CDDYRK1AIKBKETBK1 | |
| SCHEMBL31227551 | 0.73 | PIK3CA (0.53) | PIK3CAPIK3CDDYRK1ACDC7CDK2 | |
| SCHEMBL16062429 | 0.73 | PIK3CA (0.53) | PIK3CAPIK3CDDYRK1AIRAK4CDC7 | |
| Lithium Ion SCHEMBL31705974 | 0.70 | PIK3CA (0.34) | PIK3CAPIK3CDDYRK1AIRAK4IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |