Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP7 | O15540 | 3/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.45 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.37 |
| ▸ | FABP3 | P05413 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31704781 | 1.00 | FABP7 (0.46) | FABP7PIK3CAPIK3CDFABP5FABP3 | |
| SCHEMBL31705648 | 0.85 | FABP7 (0.53) | FABP7PIK3CAPIK3CDFABP5FABP3 | |
| SCHEMBL3107969 | 0.85 | FABP7 (0.53) | FABP7PIK3CAPIK3CDFABP5FABP3 | |
| SCHEMBL23715058 | 0.81 | HDAC8 (0.45) | FABP7PIK3CAPIK3CDBRD4JAK3 | |
| SCHEMBL23705406 | 0.81 | FABP7 (0.47) | FABP7PIK3CAPIK3CDPIK3CBPIK3CG | |
| Lithium Ion SCHEMBL31705859 | 0.76 | PIK3CD (0.44) | FABP7PIK3CAPIK3CDFABP5FABP3 | |
| Lithium Ion SCHEMBL31704606 | 0.76 | PIK3CD (0.44) | FABP7PIK3CAPIK3CDFABP5FABP3 | |
| SCHEMBL20499591 | 0.73 | MAPT (0.47) | FABP7PIK3CAPIK3CDFABP5FABP3 | |
| SCHEMBL22832713 | 0.72 | MAPK14 (0.50) | FABP7MAPK14 | |
| SCHEMBL6223899 | 0.72 | NQO2 (0.50) | FABP7PIK3CAJAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |