Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glutamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.86 |
| ▸ | GRM8 | O00222 | 2/20 | 0.86 |
| ▸ | GRM6 | O15303 | 2/20 | 0.86 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.86 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.86 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.86 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.86 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.86 |
| ▸ | GRM5 | P41594 | 1/20 | 0.86 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.86 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.86 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.86 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.86 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.86 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.86 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.86 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.86 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.86 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL1685060 | 1.00 | GSR (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL2680379 | 1.00 | GSR (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL28366963 | 1.00 | GSR (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL1537418 | 1.00 | GSR (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL5673029 | 1.00 | GSR (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL29024788 | 0.98 | GRM8 (0.82) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL23647298 | 0.94 | GSR (0.75) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL28325695 | 0.94 | GRM8 (0.75) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL19348263 | 0.94 | GRM8 (0.75) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL1330824 | 0.93 | GRM8 (1.00) | GSRGRM8GRM6GRM7GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025217074-A1 | KISSPEPTIN RECEPTOR (KISS1R) TARGETED THERAPEUTICS AND USES THEREOF | RADIONETICS ONCOLOGY, INC. (US) | 2025-10-16 | — | — | WO | disclosed |