Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 19/20 | 0.52 |
| ▸ | PSMB1 | P20618 | 12/20 | 0.52 |
| ▸ | PSMB11 | A5LHX3 | 11/20 | 0.52 |
| ▸ | PSMD11 | O00231 | 11/20 | 0.52 |
| ▸ | PSMD12 | O00232 | 11/20 | 0.52 |
| ▸ | PSMD14 | O00487 | 11/20 | 0.52 |
| ▸ | PSMA7 | O14818 | 11/20 | 0.52 |
| ▸ | PSMD3 | O43242 | 11/20 | 0.52 |
| ▸ | PSMC3 | P17980 | 11/20 | 0.52 |
| ▸ | PSMA1 | P25786 | 11/20 | 0.52 |
| ▸ | PSMA2 | P25787 | 11/20 | 0.52 |
| ▸ | PSMA3 | P25788 | 11/20 | 0.52 |
| ▸ | PSMA4 | P25789 | 11/20 | 0.52 |
| ▸ | PSMB8 | P28062 | 11/20 | 0.52 |
| ▸ | PSMB9 | P28065 | 11/20 | 0.52 |
| ▸ | PSMA5 | P28066 | 11/20 | 0.52 |
| ▸ | PSMB4 | P28070 | 11/20 | 0.52 |
| ▸ | PSMB6 | P28072 | 11/20 | 0.52 |
| ▸ | PSMC2 | P35998 | 11/20 | 0.52 |
| ▸ | PSMB10 | P40306 | 11/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL607466 | 0.94 | PSMB5 (0.49) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| SCHEMBL606626 | 0.93 | PSMB5 (0.54) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| SCHEMBL1478252 | 0.93 | PSMB5 (0.52) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| SCHEMBL1478345 | 0.93 | PSMB5 (0.54) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| SCHEMBL1477891 | 0.93 | PSMB5 (0.52) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| SCHEMBL607074 | 0.93 | PSMB5 (0.52) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| SCHEMBL607190 | 0.93 | PSMB5 (0.52) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| SCHEMBL608456 | 0.93 | PSMB5 (0.54) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| SCHEMBL1480392 | 0.93 | PSMB5 (0.52) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| SCHEMBL609490 | 0.93 | PSMB5 (0.52) | PSMB5PSMB1PSMB11PSMD11PSMD12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660507-B9 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2010-03-24 | — | — | EP | claimed |
| EP-1660507-B1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2009-08-05 | — | — | EP | claimed |