Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | IDH2 | P48735 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | FPR1 | P21462 | 3/20 | 0.30 |
| ▸ | FPR2 | P25090 | 3/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31713897 | 1.00 | WRN (0.47) | WRNKDM4EIDH2MAPTPIK3CD | |
| SCHEMBL31713647 | 0.91 | WRN (0.48) | WRNKDM4EMAPTPIK3CDPIK3C2B | |
| SCHEMBL31713805 | 0.90 | WRN (0.51) | WRNKDM4EIDH2MAPTPIK3CD | |
| SCHEMBL31713832 | 0.87 | WRN (0.49) | WRNKDM4EMAPTPIK3CDAKR1B1 | |
| SCHEMBL31713369 | 0.86 | WRN (0.51) | WRNKDM4EIDH2MAPTPIK3CD | |
| SCHEMBL31713726 | 0.85 | WRN (0.46) | WRNKDM4EMAPTAKR1B1TP53 | |
| SCHEMBL31713885 | 0.85 | WRN (0.47) | WRNKDM4EMAPTPIK3CDPIK3C2B | |
| SCHEMBL31713758 | 0.84 | WRN (0.50) | WRNKDM4EIDH2MAPTPIK3CD | |
| SCHEMBL31713820 | 0.84 | WRN (0.48) | WRNKDM4EIDH2MAPT | |
| SCHEMBL31713682 | 0.84 | WRN (0.47) | WRNKDM4EMAPTPIK3CDPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250333419-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF WRN | INCYTE CORPORATION (US) | 2025-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250333419-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF WRN | WRN, BLM, RECQL | WRN 1/4885KDM4E 3651/4885IDH2 1146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.