Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL316963 | 0.82 | PTGDR2 (0.73) | PTGDR2KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL2960869 | 0.81 | PTGDR2 (0.71) | PTGDR2KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL2960863 | 0.81 | PTGDR2 (0.71) | PTGDR2KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL317756 | 0.80 | PTGDR2 (0.70) | PTGDR2ALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL2960865 | 0.74 | PTGDR2 (0.61) | PTGDR2KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL318053 | 0.70 | PTGDR2 (0.75) | PTGDR2KDM4ECYP2C9CYP2C19NPSR1 | |
| SCHEMBL318378 | 0.70 | PTGDR2 (0.66) | PTGDR2HSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL1757819 | 0.66 | PTGDR2 (0.62) | PTGDR2KDM4ECYP3A4CYP2C9CYP2C19 | |
| SCHEMBL317520 | 0.65 | PTGDR2 (0.79) | PTGDR2CYP2C9CYP2C19 | |
| SCHEMBL8366867 | 0.65 | KDM4E (0.61) | KDM4EHPGDHSD17B10ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093278-B2 | Substituted indoles | ASTRAZENECA AB (SE) | 2012-01-10 | — | — | US | disclosed |