Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | BRAF | P15056 | 16/20 | 0.50 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3173747 | 0.86 | KDM4E (0.63) | KDM4EBRAFCYP17A1RAF1MAPK14 | |
| SCHEMBL3170908 | 0.86 | KDM4E (0.63) | KDM4EBRAFCYP17A1RAF1MAPK14 | |
| SCHEMBL9468075 | 0.81 | KDM4E (0.69) | KDM4EBRAFCYP17A1RAF1MAPK14 | |
| SCHEMBL3155574 | 0.81 | KDM4E (0.69) | KDM4EBRAFCYP17A1RAF1MAPK14 | |
| SCHEMBL3164198 | 0.81 | KDM4E (0.69) | KDM4EBRAFCYP17A1RAF1MAPK14 | |
| SCHEMBL4700538 | 0.81 | KDM4E (0.63) | KDM4EBRAFCYP17A1RAF1MAPK14 | |
| SCHEMBL3175469 | 0.81 | KDM4E (0.83) | KDM4EBRAF | |
| SCHEMBL11482468 | 0.81 | CLK4 (0.58) | KDM4E | |
| SCHEMBL11464152 | 0.80 | KDM4E (0.81) | KDM4EBRAF | |
| SCHEMBL8435070 | 0.79 | KDM4E (1.00) | KDM4EBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713808-B1 | TWO-PHASE METHOD FOR THE SYNTHESIS OF SELECTED PYRAZOLOPYRIMIDINES | MALLINCKRODT INC (US) | 2010-02-24 | — | — | EP | claimed |
| US-4236005-A | ANTIANXIETY | AMERICAN CYANAMID COMPANY (US) | 1980-11-25 | — | — | US | disclosed |
| US-4178449-A | Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1979-12-11 | — | — | US | disclosed |