Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL251417 | 0.94 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL2376061 | 0.94 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL5318348 | 0.94 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL18420459 | 0.94 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL35983 | 0.94 | — | — | |
| Bicarbonate SCHEMBL25206526 | 0.94 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL8991976 | 0.89 | CA4 (0.42) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL8995977 | 0.89 | CA1 (0.56) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL8995980 | 0.89 | — | — | |
| Bicarbonate SCHEMBL7043813 | 0.89 | CA4 (0.42) | CA4CA1FAHD1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0838493-B1 | Stabilizer-combination for cable insulations | BAERLOCHER GMBH (DE) | 2001-08-08 | — | — | EP | claimed |
| EP-0838493-A1 | Stabilizer-combination for cable insulations | Bärlocher GmbH (DE) | 1998-04-29 | — | — | EP | claimed |
| EP-2470592-B1 | PROCESS FOR FORMULATING STABILIZER MELTS, SHAPED BODIES PRODUCED THEREBY AND USE THEREOF | BAERLOCHER GMBH (DE) | 2016-10-12 | — | — | EP | disclosed |
| EP-2072567-B1 | Compound for stabilising polymers containing halogens, method for manufacture and use | BENE FIT SYSTEMS GMBH & CO KG (DE) | 2016-02-24 | — | — | EP | disclosed |
| EP-1692220-B1 | STABILIZING COMPOSITION FOR THERMOPLASTIC RESIN COMPOSITIONS CONTAINING HALOGEN | BAERLOCHER GMBH (DE) | 2010-03-31 | — | — | EP | disclosed |
| EP-2072567-A1 | Compound for stabilising polymers containing halogens, method for manufacture and use | Bene_fit Systems GmbH & Co. KG (DE) | 2009-06-24 | — | — | EP | disclosed |
| US-7419622-B2 | Stabilizer composition for halogen-containing thermoplastic resin compositions | BARLOCHER GMBH (DE) | 2008-09-02 | — | — | US | disclosed |
| EP-1769022-B1 | STABILIZER COMPOSITION FOR COLORED HALOGEN-CONTAINING THERMOPLASTIC RESIN COMPOSITIONS | BAERLOCHER GMBH (DE) | 2008-08-13 | — | — | EP | disclosed |
| US-20080132616-A1 | Stabiliser Composition For Halogen-Containing Thermoplastic Resin Compositions Having An Improved Shelf Life | BAERLOCHER GMBH (DE) | 2008-06-05 | — | — | US | disclosed |
| US-20080023673-A1 | Stabilizer Composition for Colored Halogen-Containing Thermoplastic Resin Compositions | BAERLOCHER GMBH (DE) | 2008-01-31 | — | — | US | disclosed |
| US-20070293612-A1 | Stabilizer Composition for Halogen-Containing Thermoplastic Resin Compositions | BAERLOCHER GMBH (DE) | 2007-12-20 | — | — | US | disclosed |
| EP-0742782-B1 | BASIC LAYERED LATTICE COMPOUNDS | CHEMSON POLYMER ADDITIVE (AT) | 1998-05-06 | — | — | EP | disclosed |
| EP-0838493-A1 | Stabilizer-combination for cable insulations | Bärlocher GmbH (DE) | 1998-04-29 | — | — | EP | disclosed |
| EP-0838493-A1 | Stabilizer-combination for cable insulations | Bärlocher GmbH (DE) | 1998-04-29 | — | — | EP | disclosed |
| EP-0771310-A1 | LATTICE LAYER COMPOUNDS AND THEIR USE | METALLGESELLSCHAFT AG (DE) | 1997-05-07 | — | — | EP | disclosed |
| EP-0771311-A1 | LATTICE LAYER COMPOUNDS AND HALOGENATED POLYMER MASS STABILISERS CONTAINING THE SAME | METALLGESELLSCHAFT AKTIENGESELLSCHAFT (DE) | 1997-05-07 | — | — | EP | disclosed |
| EP-0742782-A1 | BASIC LAYERED LATTICE COMPOUNDS | CHEMSON POLYMER-ADDITIVE GESELLSCHAFT M.B.H. (AT) | 1996-11-20 | — | — | EP | disclosed |
| WO-1996002465-A1 | LATTICE LAYER COMPOUNDS AND THEIR USE | METALLGESELLSCHAFT AKTIENGESELLSCHAFT (DE) | 1996-02-01 | — | — | WO | disclosed |
| WO-1996002466-A1 | LATTICE LAYER COMPOUNDS AND HALOGENATED POLYMER MASS STABILISERS CONTAINING THE SAME | METALLGESELLSCHAFT AKTIENGESELLSCHAFT (DE) | 1996-02-01 | — | — | WO | disclosed |
| WO-1995021127-A1 | BASIC LAYERED LATTICE COMPOUNDS | CHEMSON POLYMER-ADDITIVE GESELLSCHAFT MBH (AT) | 1995-08-10 | — | — | WO | disclosed |