Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 17/20 | 0.36 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3332022 | 0.81 | PDE7A (0.38) | PDE7APDE7B | |
| SCHEMBL24535197 | 0.81 | PDE7A (0.38) | PDE7APDE7B | |
| SCHEMBL8816271 | 0.76 | NEK2 (0.36) | PDE7A | |
| SCHEMBL29680096 | 0.76 | PDE7A (0.39) | PDE7APDE7B | |
| Trifluoroacetic Acid SCHEMBL30836075 | 0.69 | CRBN (0.36) | PDE7A | |
| SCHEMBL23651601 | 0.69 | PDE7A (0.38) | PDE7APDE7B | |
| SCHEMBL2201251 | 0.68 | CRBN (0.38) | PDE7A | |
| Hydrochloric Acid SCHEMBL31733116 | 0.67 | CRBN (0.37) | PDE7A | |
| Hydrochloric Acid SCHEMBL21292655 | 0.67 | CRBN (0.37) | PDE7A | |
| SCHEMBL31739718 | 0.66 | POLB (0.36) | PDE7ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250368649-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2025-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250368649-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | KRAS, NRAS, HRAS | PDE7A 3007/4885PDE7B 2697/4885SIGMAR1 4644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.