Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 20/20 | 1.00 |
| ▸ | PLG | P00747 | 1/20 | 0.67 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.67 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.67 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17064981 | 1.00 | KLKB1 (1.00) | KLKB1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL18605069 | 0.95 | KLKB1 (0.90) | KLKB1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL29825797 | 0.95 | KLKB1 (0.90) | KLKB1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL18604648 | 0.92 | KLKB1 (0.85) | KLKB1 | |
| SCHEMBL30415020 | 0.92 | KLKB1 (0.85) | KLKB1 | |
| SCHEMBL29825665 | 0.92 | KLKB1 (1.00) | KLKB1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL31673925 | 0.92 | KLKB1 (1.00) | KLKB1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL18605125 | 0.92 | KLKB1 (1.00) | KLKB1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL18604940 | 0.92 | KLKB1 (0.84) | KLKB1 | |
| SCHEMBL31067461 | 0.91 | KLKB1 (0.84) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4663636-A2 | TRIFLUOROMETHYL SUBSTITUTED PYRAZOLES AS HUMAN PLASMA KALLIKREIN INHIBITORS | BioCryst Pharmaceuticals, Inc. (US) | 2025-12-17 | — | — | EP | disclosed |