SCHEMBL31746963

SCHEMBL31746963

O=C(Cn1ccc2cccc(Nc3cc(F)c4[nH]ncc4c3)c2c1=O)NCC(F)(F)F

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
DDR1 Q08345 15/20 0.38
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
RAB9A P51151 1/20 0.36
NPC1 O15118 1/20 0.35
USP2 O75604 1/20 0.35
LMNA P02545 1/20 0.35
MAPK1 P28482 1/20 0.35
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CD38 P28907 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25073865 1.00 DDR1 (0.38) DDR1MEN1KMT2ARAB9ANPC1
SCHEMBL30279180 0.91 DDR1 (0.40) DDR1
SCHEMBL31746920 0.91 DDR1 (0.43) DDR1MEN1KMT2ARAB9AUSP2
SCHEMBL25073835 0.91 DDR1 (0.40) DDR1
SCHEMBL25073841 0.91 DDR1 (0.39) DDR1USP2LMNAMAPK1HTT
SCHEMBL25073872 0.91 DDR1 (0.43) DDR1MEN1KMT2ARAB9AUSP2
SCHEMBL31746916 0.90 DDR1 (0.39) DDR1MEN1KMT2AUSP2LMNA
SCHEMBL25073856 0.90 DDR1 (0.39) DDR1MEN1KMT2AUSP2LMNA
SCHEMBL25073837 0.90 PLK4 (0.37) DDR1
SCHEMBL25073895 0.89 DDR1 (0.36) DDR1USP2LMNAMAPK1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4387963-B1 PHENYL- AND PYRIDOPYRAZOLE DERIVATIVES AS INHIBITORS OF DDR1 REDX PHARMA LTD (GB) 2025-12-24 EP disclosed