Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 5/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | ALB | P02768 | 2/20 | 0.60 |
| ▸ | VKORC1 | Q9BQB6 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | NQO1 | P15559 | 7/20 | 0.56 |
| ▸ | TOP1 | P11387 | 1/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3177410 | 1.00 | CYP2C9 (0.60) | CYP2C9HSD17B10ALBVKORC1KDM4E | |
| SCHEMBL3158084 | 1.00 | CYP2C9 (0.60) | CYP2C9HSD17B10ALBVKORC1KDM4E | |
| SCHEMBL1649090 | 0.87 | CYP2C9 (0.73) | CYP2C9HSD17B10ALBVKORC1KDM4E | |
| SCHEMBL1649084 | 0.87 | NQO1 (0.70) | CYP2C9HSD17B10ALBVKORC1KDM4E | |
| SCHEMBL1649909 | 0.85 | CYP2C9 (0.80) | CYP2C9HSD17B10ALBVKORC1KDM4E | |
| SCHEMBL1649918 | 0.85 | NQO1 (0.72) | CYP2C9HSD17B10ALBVKORC1KDM4E | |
| SCHEMBL28246100 | 0.84 | NQO1 (0.74) | CYP2C9KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL12777877 | 0.81 | CYP2C9 (0.48) | CYP2C9HSD17B10ALBVKORC1KDM4E | |
| SCHEMBL14078679 | 0.81 | TOP2A (0.62) | CYP2C9HSD17B10ALBVKORC1KDM4E | |
| SCHEMBL1649099 | 0.81 | CYP2C9 (0.57) | CYP2C9HSD17B10ALBVKORC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2161261-B1 | Materials and methods for treating coagulation disorders | ARMETHEON INC (US) | 2013-08-28 | — | — | EP | disclosed |
| EP-2161261-A1 | Materials and methods for treating coagulation disorders | Aryx Therapeutics (US) | 2010-03-10 | — | — | EP | disclosed |
| EP-1735296-B1 | MATERIALS AND METHODS FOR TREATING COAGULATION DISORDERS | ARYX THERAPEUTICS (US) | 2009-12-09 | — | — | EP | disclosed |
| US-20080221204-A1 | Materials and Methods for Treating Coagulation Disorders | DRUZGALA PASCAL | 2008-09-11 | — | — | US | disclosed |
| US-20080221204-A1 | Materials and Methods for Treating Coagulation Disorders | DRUZGALA PASCAL | 2008-09-11 | — | — | US | disclosed |
| US-20070129429-A1 | Materials And Methods For Treating Coagulation Disorders | ARYX THERAPEUTICS, INC. | 2007-06-07 | — | — | US | disclosed |
| US-20070129429-A1 | Materials And Methods For Treating Coagulation Disorders | ARYX THERAPEUTICS, INC. | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221204-A1 | Materials and Methods for Treating Coagulation Disorders | CES1, F2, CYP3A5 | CYP2C9 24/4885HSD17B10 257/4885ALB 1199/4885 |
| US-20070129429-A1 | Materials And Methods For Treating Coagulation Disorders | CES1, F2, CYP3A5 | CYP2C9 24/4885HSD17B10 257/4885ALB 1199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.