Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | XIAP | P98170 | 1/20 | 0.49 |
| ▸ | TPH1 | P17752 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25657792 | 0.80 | HSD17B10 (0.53) | HSD17B10SLC7A5PTGS1PKMALPI | |
| SCHEMBL2263843 | 0.79 | SLC7A5 (0.55) | HSD17B10SLC7A5PTGS1PKMALPI | |
| SCHEMBL28759077 | 0.79 | SLC7A5 (0.55) | HSD17B10SLC7A5PTGS1PKMALPI | |
| SCHEMBL15314365 | 0.79 | SLC7A5 (0.55) | HSD17B10SLC7A5PTGS1PKMALPI | |
| SCHEMBL31000724 | 0.77 | SLC7A5 (0.53) | HSD17B10SLC7A5PTGS1PKMALPI | |
| SCHEMBL21643035 | 0.75 | HSD17B10 (0.39) | HSD17B10SLC7A5PTGS1PKMALPI | |
| SCHEMBL21643037 | 0.75 | HSD17B10 (0.39) | HSD17B10SLC7A5PTGS1PKMALPI | |
| SCHEMBL31370308 | 0.73 | HSD17B10 (0.49) | HSD17B10SLC7A5PTGS1PKMALPI | |
| SCHEMBL31754300 | 0.73 | HSD17B10 (0.49) | HSD17B10SLC7A5PTGS1PKMALPI | |
| SCHEMBL13585683 | 0.73 | SLC7A5 (0.57) | HSD17B10SLC7A5PTGS1PKMALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260001914-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | MERCK SHARP & DOHME LLC (US) | 2026-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260001914-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | KRAS, NRAS, HRAS | HSD17B10 4549/4885SLC7A5 308/4885PTGS1 3843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.