Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 20/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TACR2 | P21452 | 1/20 | 0.60 |
| ▸ | TACR3 | P29371 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4985872 | 1.00 | TACR1 (1.00) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL12646290 | 1.00 | TACR1 (1.00) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL4985877 | 1.00 | TACR1 (1.00) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL12902066 | 1.00 | TACR1 (1.00) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL4991602 | 1.00 | TACR1 (1.00) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL3264264 | 1.00 | TACR1 (1.00) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL14361057 | 1.00 | TACR1 (1.00) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL3172961 | 1.00 | TACR1 (1.00) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL3167448 | 1.00 | TACR1 (1.00) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL3167453 | 1.00 | TACR1 (1.00) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10278952-B2 | Use of NK-1 receptor antagonists in pruritus | MENLO THERAPEUTICS INC. (US) | 2019-05-07 | — | — | US | disclosed |
| US-10278953-B2 | Use of NK-1 receptor antagonist serlopitant in pruritus | MENLO THERAPEUTICS INC. (US) | 2019-05-07 | — | — | US | disclosed |
| US-9737508-B2 | Use of NK-1 receptor antagonists in pruritus | MENLO THERAPEUTICS INC. (US) | 2017-08-22 | — | — | US | disclosed |
| US-9707209-B2 | — | — | 2017-07-18 | — | — | US | disclosed |
| US-20170065558-A1 | USE OF NK-1 RECEPTOR ANTAGONISTS IN PRURITUS | VYNE THERAPEUTICS INC. (F/K/A MENLO THERAPEUTICS INC. AND SUCCESSOR-IN-INTEREST TO VYNE PHARMACEUTICALS LTD., F/K/A FOAMIX PHARMACEUTICALS LTD.) | 2017-03-09 | — | — | US | disclosed |
| US-9486439-B2 | Use of NK-1 receptor antagonist serlopitant in pruritus | MENLO THERAPEUTICS INC. (US) | 2016-11-08 | — | — | US | disclosed |
| US-9474741-B2 | Use of NK-1 receptor antagonists in pruritus | MENLO THERAPEUTICS INC. (US) | 2016-10-25 | — | — | US | disclosed |
| US-20160279100-A1 | USE OF NK-1 RECEPTOR ANTAGONISTS IN PRURITUS | VYNE THERAPEUTICS INC. (F/K/A MENLO THERAPEUTICS INC. AND SUCCESSOR-IN-INTEREST TO VYNE PHARMACEUTICALS LTD., F/K/A FOAMIX PHARMACEUTICALS LTD.) | 2016-09-29 | — | — | US | disclosed |
| US-9381188-B2 | Use of NK-1 receptor antagonists in pruritus | Tigercat Pharma, Inc. (US) | 2016-07-05 | — | — | US | disclosed |
| US-20160143882-A1 | USE OF NK-1 RECEPTOR ANTAGONIST SERLOPITANT IN PRURITUS | VYNE THERAPEUTICS INC. (F/K/A MENLO THERAPEUTICS INC. AND SUCCESSOR-IN-INTEREST TO VYNE PHARMACEUTICALS LTD., F/K/A FOAMIX PHARMACEUTICALS LTD.) | 2016-05-26 | — | — | US | disclosed |
| US-20070161695-A1 | Hydroisoindoline tachykinin receptor antagonists | VYNE THERAPEUTICS INC. (F/K/A MENLO THERAPEUTICS INC. AND SUCCESSOR-IN-INTEREST TO VYNE PHARMACEUTICALS LTD., F/K/A FOAMIX PHARMACEUTICALS LTD.) | 2007-07-12 | — | — | US | disclosed |
| US-20070161695-A1 | Hydroisoindoline tachykinin receptor antagonists | VYNE THERAPEUTICS INC. (F/K/A MENLO THERAPEUTICS INC. AND SUCCESSOR-IN-INTEREST TO VYNE PHARMACEUTICALS LTD., F/K/A FOAMIX PHARMACEUTICALS LTD.) | 2007-07-12 | — | — | US | disclosed |
| US-7217731-B2 | Hydroisoindoline tachykinin receptor antagonists | MERCK & CO., INC. (US) | 2007-05-15 | — | — | US | disclosed |
| US-7217731-B2 | Hydroisoindoline tachykinin receptor antagonists | MERCK & CO., INC. (US) | 2007-05-15 | — | — | US | disclosed |
| US-7217731-B2 | Hydroisoindoline tachykinin receptor antagonists | MERCK & CO., INC. (US) | 2007-05-15 | — | — | US | disclosed |
| WO-2007044296-A2 | COMBINATION THERAPY FOR THE TREATMENT OF URINARY FREQUENCY, URINARY URGENCY AND URINARY INCONTINENCE | MERCK & CO., INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| US-20070015923-A1 | Process for making hydroisoindoline tachykinin receptor antagonists | MERCK SHARP & DOHME CORP. | 2007-01-18 | — | — | US | disclosed |
| US-20070015923-A1 | Process for making hydroisoindoline tachykinin receptor antagonists | MERCK SHARP & DOHME CORP. | 2007-01-18 | — | — | US | disclosed |
| WO-2007008564-A1 | PROCESS FOR MAKING HYDROISOINDOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-01-18 | — | — | WO | disclosed |
| US-20050165083-A1 | Hydroisoindoline tachykinin receptor antagonists | VYNE THERAPEUTICS INC. (F/K/A MENLO THERAPEUTICS INC. AND SUCCESSOR-IN-INTEREST TO VYNE PHARMACEUTICALS LTD., F/K/A FOAMIX PHARMACEUTICALS LTD.) | 2005-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165083-A1 | Hydroisoindoline tachykinin receptor antagonists | TACR1, TACR2, NPSR1 | TACR1 1/4885CYP3A4 3228/4885CYP2C8 3154/4885 |
| US-10278952-B2 | Use of NK-1 receptor antagonists in pruritus | TACR1, CYSLTR1, HRH3 | TACR1 1/4885CYP3A4 774/4885CYP2C8 1404/4885 |
| US-20070161695-A1 | Hydroisoindoline tachykinin receptor antagonists | TACR1, TACR2, NPSR1 | TACR1 1/4885CYP3A4 3228/4885CYP2C8 3154/4885 |
| US-20170065558-A1 | USE OF NK-1 RECEPTOR ANTAGONISTS IN PRURITUS | TACR1, CYSLTR1, HRH3 | TACR1 1/4885CYP3A4 774/4885CYP2C8 1404/4885 |
| US-20160143882-A1 | USE OF NK-1 RECEPTOR ANTAGONIST SERLOPITANT IN PRURITUS | TACR1, CYSLTR1, NPSR1 | TACR1 1/4885CYP3A4 849/4885CYP2C8 1425/4885 |
| US-20160279100-A1 | USE OF NK-1 RECEPTOR ANTAGONISTS IN PRURITUS | TACR1, CYSLTR1, HRH3 | TACR1 1/4885CYP3A4 774/4885CYP2C8 1404/4885 |
| US-20070015923-A1 | Process for making hydroisoindoline tachykinin receptor antagonists | TACR1, TACR2, NPSR1 | TACR1 1/4885CYP3A4 2681/4885CYP2C8 3095/4885 |
| US-10278953-B2 | Use of NK-1 receptor antagonist serlopitant in pruritus | TACR1, CYSLTR1, NPSR1 | TACR1 1/4885CYP3A4 849/4885CYP2C8 1425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.