Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.61 |
| ▸ | CA1 | P00915 | 3/20 | 0.61 |
| ▸ | CA2 | P00918 | 3/20 | 0.61 |
| ▸ | CA7 | P43166 | 3/20 | 0.61 |
| ▸ | CA9 | Q16790 | 3/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.61 |
| ▸ | TPMT | P51580 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | CA3 | P07451 | 2/20 | 0.58 |
| ▸ | CA4 | P22748 | 2/20 | 0.58 |
| ▸ | CA6 | P23280 | 2/20 | 0.58 |
| ▸ | CA5A | P35218 | 2/20 | 0.58 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | SELL | P14151 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | SELP | P16109 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26189 | 0.96 | CA12 (0.65) | CA12CA1CA2CA7CA9 | |
| SCHEMBL22982 | 0.96 | CA12 (0.65) | CA12CA1CA2CA7CA9 | |
| Iodide SCHEMBL3185412 | 0.92 | CA12 (0.61) | CA12CA1CA2CA7CA9 | |
| SCHEMBL21590118 | 0.92 | CA12 (0.61) | CA12CA1CA2CA7CA9 | |
| Hydrochloric Acid SCHEMBL3704383 | 0.92 | CA12 (0.61) | CA12CA1CA2CA7CA9 | |
| SCHEMBL23004950 | 0.92 | CA12 (0.61) | CA12CA1CA2CA7CA9 | |
| Hydrochloric Acid SCHEMBL3704386 | 0.92 | CA12 (0.61) | CA12CA1CA2CA7CA9 | |
| Hydrochloric Acid SCHEMBL93749 | 0.92 | CA12 (0.61) | CA12CA1CA2CA7CA9 | |
| Potassium SCHEMBL30862175 | 0.92 | CA12 (0.61) | CA12CA1CA2CA7CA9 | |
| SCHEMBL15789102 | 0.92 | CA12 (0.61) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104582822-B | Amino silicone flux enhancers for improving composite polyamide reverse osmose membrane performance | 通用电气公司 | 2017-06-13 | — | — | CN | claimed |
| US-9346023-B2 | Flux enhancing agent for improving composite polyamide reverse osmosis membrane performance | GENERAL ELECTRIC COMPANY (US) | 2016-05-24 | — | — | US | claimed |
| EP-2888030-A1 | AMINO-SILOXANE FLUX ENHANCING AGENT FOR IMPROVING COMPOSITE POLYAMIDE REVERSE!OSMOSIS MEMBRANE PERFORMANCE | General Electric Company (US) | 2015-07-01 | — | — | EP | claimed |
| CN-104582822-A | Amino-siloxane flux enhancing agent for improving composite polyamide reverse osmosis membrane performance | GEN ELECTRIC | 2015-04-29 | — | — | CN | claimed |
| WO-2014031271-A1 | AMINO-SILOXANE FLUX ENHANCING AGENT FOR IMPROVING COMPOSITE POLYAMIDE REVERSE|OSMOSIS MEMBRANE PERFORMANCE | GENERAL ELECTRIC COMPANY (US) | 2014-02-27 | — | — | WO | claimed |
| US-20140054228-A1 | Novel Flux Enhancing Agent for Improving Composite Polyamide Reverse Osmosis Membrane Performance | GENERAL ELECTRIC COMPANY (US) | 2014-02-27 | — | — | US | claimed |
| US-9914098-B2 | Flux enhancing agent for improving composite polyamide reverse osmosis membrane performance | BL TECHNOLOGIES, INC. | 2018-03-13 | — | — | US | disclosed |
| CN-104582822-B | Amino silicone flux enhancers for improving composite polyamide reverse osmose membrane performance | 通用电气公司 | 2017-06-13 | — | — | CN | disclosed |
| US-20160193572-A1 | Novel Flux Enhancing Agent for Improving Composite Polyamide Reverse Osmosis Membrane Performance | BL TECHNOLOGIES, INC. | 2016-07-07 | — | — | US | disclosed |
| US-9346023-B2 | Flux enhancing agent for improving composite polyamide reverse osmosis membrane performance | GENERAL ELECTRIC COMPANY (US) | 2016-05-24 | — | — | US | disclosed |
| US-9314743-B2 | Residential reverse osmosis system | PENTAIR RESIDENTIAL FILTRATION, LLC (US) | 2016-04-19 | — | — | US | disclosed |
| EP-2888030-A1 | AMINO-SILOXANE FLUX ENHANCING AGENT FOR IMPROVING COMPOSITE POLYAMIDE REVERSE!OSMOSIS MEMBRANE PERFORMANCE | General Electric Company (US) | 2015-07-01 | — | — | EP | disclosed |
| CN-104582822-A | Amino-siloxane flux enhancing agent for improving composite polyamide reverse osmosis membrane performance | GEN ELECTRIC | 2015-04-29 | — | — | CN | disclosed |
| US-5271843-A | Chlorine-tolerant, thin-film composite membrane | ALLIED-SIGNAL INC. (US) | 1993-12-21 | — | — | US | disclosed |
| EP-0489746-B1 | HIGH FLUX SEMIPERMEABLE MEMBRANES | AlliedSignal Inc. (US) | 1993-07-07 | — | — | EP | disclosed |
| EP-0489746-A1 | HIGH FLUX SEMIPERMEABLE MEMBRANES. | ALLIED SIGNAL INC (US) | 1992-06-17 | — | — | EP | disclosed |
| WO-1991003311-A1 | HIGH FLUX SEMIPERMEABLE MEMBRANES | ALLIED-SIGNAL INC. (US) | 1991-03-21 | — | — | WO | disclosed |
| US-4983291-A | Reverse osmosis, desalination, coating support with polyamine, reacting with polyacyl halide, polysulfonyl halide or polyisocyanate | ALLIED-SIGNAL INC. (US) | 1991-01-08 | — | — | US | disclosed |
| US-4950404-A | REVERSE OSMOSIS; WATER DESLINATION | ALLIED-SIGNAL INC. (US) | 1990-08-21 | — | — | US | disclosed |
| US-4830885-A | POLYAMIDES | ALLIED-SIGNAL INC. (US) | 1989-05-16 | — | — | US | disclosed |