Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.64 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 4/20 | 0.43 |
| ▸ | MAOA | P21397 | 4/20 | 0.43 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3178393 | 1.00 | HDAC1 (0.64) | HDAC1NR1H2ESR2MAPTKDM4E | |
| SCHEMBL20367229 | 0.96 | HDAC1 (0.64) | HDAC1NR1H2ESR2MAPTKDM4E | |
| SCHEMBL3178100 | 0.93 | HDAC1 (0.57) | HDAC1NR1H2ESR2MAPTKDM4E | |
| SCHEMBL3178096 | 0.93 | HDAC1 (0.57) | HDAC1NR1H2ESR2MAPTKDM4E | |
| SCHEMBL3184355 | 0.91 | HDAC1 (0.77) | HDAC1NR1H2ESR2MAPTKDM4E | |
| SCHEMBL3184350 | 0.91 | HDAC1 (0.77) | HDAC1NR1H2ESR2MAPTKDM4E | |
| SCHEMBL3177427 | 0.89 | HDAC1 (0.62) | HDAC1NR1H2ESR2MAPTKDM4E | |
| SCHEMBL3177432 | 0.89 | HDAC1 (0.62) | HDAC1NR1H2ESR2MAPTKDM4E | |
| SCHEMBL27766220 | 0.85 | KDM4E (0.48) | HDAC1MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL20162169 | 0.84 | ESR2 (0.65) | HDAC1NR1H2ESR2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022514-A1 | Heterocycle Compounds and Methods of Use Thereof | NORVARTIS AG | 2010-01-28 | — | — | US | disclosed |
| US-20100022514-A1 | Heterocycle Compounds and Methods of Use Thereof | NORVARTIS AG | 2010-01-28 | — | — | US | disclosed |
| US-20100022514-A1 | Heterocycle Compounds and Methods of Use Thereof | NORVARTIS AG | 2010-01-28 | — | — | US | disclosed |
| EP-2120910-A2 | HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF | Novartis Ag (CH) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008076954-A2 | HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF | NOVARTIS AG (CH) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076954-A2 | HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF | NOVARTIS AG (CH) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022514-A1 | Heterocycle Compounds and Methods of Use Thereof | HDAC1, HDAC3, HDAC10 | HDAC1 1/4885NR1H2 327/4885ESR2 2057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.