Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.69 |
| ▸ | RET | P07949 | 2/20 | 0.69 |
| ▸ | GAK | O14976 | 1/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.69 |
| ▸ | ULK1 | O75385 | 1/20 | 0.69 |
| ▸ | STK10 | O94804 | 1/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.69 |
| ▸ | LATS1 | O95835 | 1/20 | 0.69 |
| ▸ | PAK4 | O96013 | 1/20 | 0.69 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.69 |
| ▸ | LCK | P06239 | 1/20 | 0.69 |
| ▸ | CDK1 | P06493 | 1/20 | 0.69 |
| ▸ | APRT | P07741 | 1/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.69 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.69 |
| ▸ | NQO2 | P16083 | 1/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.69 |
| ▸ | FECH | P22830 | 1/20 | 0.69 |
| ▸ | CDK2 | P24941 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20127052 | 0.93 | IRAK4 (0.69) | IRAK4RETGAKRIPK2ULK1 | |
| SCHEMBL3175049 | 0.90 | IRAK4 (0.64) | IRAK4RETGAKRIPK2ULK1 | |
| SCHEMBL3189410 | 0.89 | IRAK4 (0.55) | IRAK4RETGAKRIPK2ULK1 | |
| SCHEMBL22097637 | 0.89 | IRAK4 (0.69) | IRAK4RETGAKRIPK2ULK1 | |
| SCHEMBL3184856 | 0.89 | IRAK4 (0.55) | IRAK4RETGAKRIPK2ULK1 | |
| SCHEMBL3184159 | 0.89 | IRAK4 (0.55) | IRAK4RETGAKRIPK2ULK1 | |
| SCHEMBL3192373 | 0.88 | IRAK4 (0.54) | IRAK4RETGAKRIPK2ULK1 | |
| SCHEMBL3184699 | 0.88 | IRAK4 (0.54) | IRAK4RETGAKRIPK2ULK1 | |
| SCHEMBL3194586 | 0.88 | RET (0.53) | IRAK4RETGAKRIPK2ULK1 | |
| SCHEMBL5763184 | 0.87 | IRAK4 (0.71) | IRAK4RETGAKRIPK2ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100016353-A1 | BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | HENNE KIRK RUSSELL | 2010-01-21 | — | — | US | claimed |
| EP-1799670-A1 | BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | Pfizer Products Inc. (US) | 2007-06-27 | — | — | EP | claimed |
| WO-2006038111-A1 | BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PRODUCTS INC. (US) | 2006-04-13 | — | — | WO | claimed |
| US-20100016353-A1 | BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | HENNE KIRK RUSSELL | 2010-01-21 | — | — | US | disclosed |
| US-20100016353-A1 | BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | HENNE KIRK RUSSELL | 2010-01-21 | — | — | US | disclosed |
| US-20100016353-A1 | BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | HENNE KIRK RUSSELL | 2010-01-21 | — | — | US | disclosed |
| EP-1799670-A1 | BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | Pfizer Products Inc. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006038111-A1 | BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PRODUCTS INC. (US) | 2006-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016353-A1 | BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | CCNI, MKI67, CCNT1 | IRAK4 1170/4885RET 1805/4885GAK 387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.