Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.73 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | STK25 | O00506 | 1/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | MUSK | O15146 | 1/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4313197 | 0.94 | AURKA (0.74) | AURKAAURKBFGFR1FLT1MAP4K4 | |
| SCHEMBL4313205 | 0.94 | AURKA (0.74) | AURKAAURKBFGFR1FLT1MAP4K4 | |
| SCHEMBL4320834 | 0.92 | AURKA (0.73) | AURKAAURKBFGFR1FLT1MAP4K4 | |
| SCHEMBL4320842 | 0.92 | AURKA (0.73) | AURKAAURKBFGFR1FLT1MAP4K4 | |
| SCHEMBL14989031 | 0.92 | AURKB (0.72) | AURKAAURKBMAP4K4NTRK1FLT3 | |
| SCHEMBL4326126 | 0.92 | AURKA (0.74) | AURKAAURKBFGFR1FLT1MAP4K4 | |
| SCHEMBL4317456 | 0.92 | AURKA (0.76) | AURKAAURKBFGFR1FLT1MAP4K4 | |
| SCHEMBL4326122 | 0.92 | AURKA (0.74) | AURKAAURKBFGFR1FLT1MAP4K4 | |
| SCHEMBL14989033 | 0.92 | AURKB (0.72) | AURKAAURKBMAP4K4NTRK1FLT3 | |
| SCHEMBL4317450 | 0.92 | AURKA (0.76) | AURKAAURKBFGFR1FLT1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101111483-B | IGF-1R inhibitors | KYOWA HAKKO KIRIN CO.,LTD. (JP) | 2011-12-14 | — | — | CN | claimed |
| WO-2012026511-A1 | PHARMACEUTICAL COMPOSITION | 協和発酵キリン株式会社 (JP) | 2012-03-01 | — | — | WO | disclosed |