Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19083300 | 0.88 | NR1H2 (0.53) | NR1H2USP2SMN1; SMN2NAMPTCHRM2 | |
| SCHEMBL13098438 | 0.88 | NR1H2 (0.53) | NR1H2USP2SMN1; SMN2NAMPTCHRM2 | |
| SCHEMBL9972997 | 0.88 | NR1H2 (0.53) | NR1H2USP2SMN1; SMN2NAMPTCHRM2 | |
| SCHEMBL15866101 | 0.87 | NR1H2 (0.49) | NR1H2USP2SMN1; SMN2NAMPTCHRM2 | |
| SCHEMBL14222487 | 0.87 | NR1H2 (0.49) | NR1H2USP2SMN1; SMN2NAMPTCHRM2 | |
| SCHEMBL19064075 | 0.86 | NR1H2 (0.48) | NR1H2USP2SMN1; SMN2NAMPTCHRM2 | |
| SCHEMBL19064074 | 0.86 | NR1H2 (0.48) | NR1H2USP2SMN1; SMN2NAMPTCHRM2 | |
| SCHEMBL19064078 | 0.86 | NR1H2 (0.48) | NR1H2USP2SMN1; SMN2NAMPTCHRM2 | |
| SCHEMBL19123415 | 0.86 | NR1H2 (0.48) | NR1H2USP2SMN1; SMN2NAMPTCHRM2 | |
| SCHEMBL19063712 | 0.84 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2NAMPTCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590360-B1 | PROCESS FOR PREPARING INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES | IND RES LTD (NZ) | 2012-07-11 | — | — | EP | disclosed |
| US-20100094003-A1 | Process for preparing inhibitors of nucleoside phosphorylases and nucleosidases | EVANS GARY BRIAN | 2010-04-15 | — | — | US | disclosed |
| US-7655795-B2 | (3R,4R)-1-[(9-deazahypoxanthin-9-yl)methyl]-3-hydroxy-4-hydroxymethyl-pyrrolidine; reaction of formaldehydewith a cyclic amine and a heteroaromatic compound to give methylene linked cyclic amine deazapurines; cancer, bacterial, protozoal infections or T-cell mediated diseases | INDUSTRIAL RESEARCH LIMITED (NZ) | 2010-02-02 | — | — | US | disclosed |
| US-20060217551-A1 | Process for preparing inhibitors of nucleoside phosphorylases and nucleosidases | INDUSTRIAL RESEARCH LIMITED (NZ) | 2006-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060217551-A1 | Process for preparing inhibitors of nucleoside phosphorylases and nucleosidases | PNP, MTAP, TYMP | NR1H2 4417/4885USP2 3379/4885SMN1; SMN2 2999/4885 |
| US-20100094003-A1 | Process for preparing inhibitors of nucleoside phosphorylases and nucleosidases | PNP, MTAP, TYMP | NR1H2 4417/4885USP2 3379/4885SMN1; SMN2 2999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.