⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11189447 | 0.98 | — | — | |
| Methane SCHEMBL27503900 | 0.98 | — | — | |
| Methane SCHEMBL27502844 | 0.95 | IKBKB (0.34) | — | |
| SCHEMBL1992222 | 0.72 | — | — | |
| SCHEMBL1492367 | 0.72 | — | — | |
| SCHEMBL9004978 | 0.72 | — | — | |
| SCHEMBL544996 | 0.70 | — | — | |
| SCHEMBL15287122 | 0.70 | — | — | |
| SCHEMBL128844 | 0.70 | — | — | |
| SCHEMBL14012626 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5043573-A | — | — | None | — | — | JP | disclosed |
| CN-118359634-A | Pyrazole derivative and medical use thereof | 正大天晴药业集团股份有限公司 | 2024-07-19 | — | — | CN | disclosed |
| US-20230348401-A1 | Inhibitors of Glucose-6-phosphate Dehydrogenase and Uses Thereof | THE TRUSTEES OF PRINCETON UNIVERSITY | 2023-11-02 | — | — | US | disclosed |
| US-20230348401-A1 | Inhibitors of Glucose-6-phosphate Dehydrogenase and Uses Thereof | THE TRUSTEES OF PRINCETON UNIVERSITY | 2023-11-02 | — | — | US | disclosed |
| US-11708333-B2 | Human plasma kallikrein inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| US-11708333-B2 | Human plasma kallikrein inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| US-11708332-B2 | Human plasma kallikrein inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| US-11708332-B2 | Human plasma kallikrein inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| EP-4180424-A1 | SUBSTITUTED PYRAZOLES AS HUMAN PLASMA KALLIKREIN INHIBITORS | BioCryst Pharmaceuticals, Inc. (US) | 2023-05-17 | — | — | EP | disclosed |
| WO-2023016518-A1 | HETEROCYCLIC DERIVATIVE, AND COMPOSITION AND PHARMACEUTICAL USE THEREOF | 四川海思科制药有限公司 | 2023-02-16 | — | — | WO | disclosed |
| US-20050192253-A1 | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function | SALVATI MARK E (US) | 2005-09-01 | — | — | US | disclosed |
| US-20050119228-A1 | METHOD FOR THE PREPARATION OF FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2005-06-02 | — | — | US | disclosed |
| EP-1458723-A1 | FUSED HETEROCYCLIC SUCCINIMIDECOMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | Bristols-Myers Squibb Company (US) | 2004-09-22 | — | — | EP | disclosed |
| US-20040077605-A1 | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function | BRISTOL-MYERS SQUIBB COMPANY | 2004-04-22 | — | — | US | disclosed |
| WO-2003062241-A1 | FUSED HETEROCYCLIC SUCCINIMIDECOMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-07-31 | — | — | WO | disclosed |
| JP-H0543573-A | CYANOGUANIDINE DERIVATIVE | KANEBO LTD | 1993-02-23 | — | — | JP | disclosed |
| EP-0150291-B1 | SUBSTITUTED 5-HYDROXY-2,3-DIHYDROBENZOFURANS AND 6-HYDROXY-2,3-DIHYDROBENZOPYRANS AND ANALOGUES THEREOF USEFUL AS ANTI-INFLAMMATORY AGENTS | MERCK & CO. INC. (US) | 1989-03-15 | — | — | EP | disclosed |
| US-4563476-A | TOPICAL, SKIN DISORDERS | MERCK & CO., INC. (US) | 1986-01-07 | — | — | US | disclosed |
| US-4382143-A | Hypolipidemic and antiatherosclerotic novel (monosubstituted-amino)heteroaryl carboxylic acids and analogs | AMERICAN CYANAMID COMPANY (US) | 1983-05-03 | — | — | US | disclosed |
| EP-0003663-A2 | Amino-substituted phenyl and heteroaryl compounds, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1979-08-22 | — | — | EP | disclosed |