Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 2/20 | 0.66 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.66 |
| ▸ | CDK1 | P06493 | 1/20 | 0.66 |
| ▸ | CDK2 | P24941 | 1/20 | 0.66 |
| ▸ | GSK3B | P49841 | 1/20 | 0.66 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.66 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.66 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.66 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.66 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.66 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.66 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.66 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.66 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.66 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.66 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 6/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3184706 | 0.90 | FLT3 (0.53) | CDK7DYRK3CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL3206299 | 0.88 | CDK7 (0.65) | CDK7DYRK3CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL3207484 | 0.87 | CDK7 (0.59) | CDK7DYRK3CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL3202835 | 0.87 | CDK7 (0.68) | CDK7DYRK3CDK1CDK2GSK3B | |
| SCHEMBL5697755 | 0.85 | CDK7 (0.61) | CDK7DYRK3CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL3203600 | 0.85 | CDK7 (0.61) | CDK7DYRK3CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL3196989 | 0.85 | CDK7 (0.67) | CDK7DYRK3CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL3184742 | 0.85 | CDK7 (0.60) | CDK7DYRK3CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL3192479 | 0.83 | DYRK3 (0.60) | CDK7DYRK3CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL3193157 | 0.83 | DYRK3 (0.54) | CDK7DYRK3CDK1CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1886397-A | 3-heterocyclyl-indole derivatives as inhibitors of glycogen synthase kinase-3 (gsk-3) | ASTRAZENECA AB (SE) | 2006-12-27 | — | — | CN | claimed |
| EP-1667990-A2 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2006-06-14 | — | — | EP | claimed |
| WO-2005027823-A2 | 3-HETEROCYCLYL-INDOLE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) | ASTRAZENECA AB (SE) | 2005-03-31 | — | — | WO | claimed |
| US-7683067-B2 | 3-heterocyclyl-indole derivatives as inhibitors of glycogen synthase kinase-3 (GSK-3) | ASTRAZENECA AB (SE) | 2010-03-23 | — | — | US | disclosed |
| US-20080275041-A1 | 3-Heterocyclyl-Indole Derivatives as Inhibitors of Glycogen Synthase Kinase-3 (Gsk-3) | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | US | disclosed |
| CN-1886397-A | 3-heterocyclyl-indole derivatives as inhibitors of glycogen synthase kinase-3 (gsk-3) | ASTRAZENECA AB (SE) | 2006-12-27 | — | — | CN | disclosed |
| EP-1667990-A2 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005027823-A2 | 3-HETEROCYCLYL-INDOLE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) | ASTRAZENECA AB (SE) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275041-A1 | 3-Heterocyclyl-Indole Derivatives as Inhibitors of Glycogen Synthase Kinase-3 (Gsk-3) | GSK3B, GSK3A, GSKIP | CDK7 131/4885DYRK3 108/4885CDK1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.