SCHEMBL319157 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	PIM1	P11309	7/20	0.44

▸	PIM3	Q86V86	4/20	0.43

▸	PIM2	Q9P1W9	4/20	0.43

▸	AKR1C3	P42330	1/20	0.35

▸	AKR1C2	P52895	1/20	0.35

▸	JAK2	O60674	1/20	0.34

▸	JAK3	P52333	1/20	0.34

▸	KCNH2	Q12809	1/20	0.34

▸	CTSA	P10619	1/20	0.34

▸	KDM4E	B2RXH2	3/20	0.33

▸	TDP1	Q9NUW8	2/20	0.33

▸	ALOX15	P16050	1/20	0.33

▸	TSHR	P16473	1/20	0.33

▸	ACMSD	Q8TDX5	1/20	0.33

▸	TNKS	O95271	4/20	0.33

▸	PARP1	P09874	4/20	0.33

▸	TNKS2	Q9H2K2	4/20	0.33

▸	MAPT	P10636	1/20	0.33

▸	RAB9A	P51151	1/20	0.33

▸	L3MBTL1	Q9Y468	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL30097121	0.87	PIM1 (0.47)	PIM1PIM3PIM2JAK2JAK3
SCHEMBL12687456	0.87	PIM1 (0.39)	PIM1PIM3PIM2AKR1C3AKR1C2
SCHEMBL29599949	0.85	PIM1 (0.47)	PIM1PIM3PIM2JAK2JAK3
SCHEMBL12079005	0.85	PIM1 (0.35)	PIM1PIM3PIM2AKR1C3AKR1C2
SCHEMBL326667	0.85	PIM1 (0.47)	PIM1PIM3PIM2JAK2JAK3
SCHEMBL12077217	0.85	PIM1 (0.38)	PIM1PIM3PIM2AKR1C3AKR1C2
SCHEMBL12077629	0.83	FFAR1 (0.34)	PIM1PIM3PIM2KDM4ETDP1
SCHEMBL318655	0.82	PIM1 (0.40)	PIM1PIM3PIM2KDM4ETDP1
SCHEMBL12078753	0.82	AKR1C3 (0.36)	PIM1PIM3PIM2AKR1C3AKR1C2
SCHEMBL12077635	0.82	PIM1 (0.35)	PIM1PIM3PIM2AKR1C3AKR1C2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-4186897-A1	PYRIDINECARBOXAMIDE COMPOUND USEFUL AS PIM KINASE INHIBITOR	Incyte Holdings Corporation (US)	2023-05-31	—	—	EP	disclosed
EP-4186897-A1	PYRIDINECARBOXAMIDE COMPOUND USEFUL AS PIM KINASE INHIBITOR	Incyte Holdings Corporation (US)	2023-05-31	—	—	EP	disclosed
EP-3670506-B1	THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS	INCYTE HOLDINGS CORP (US)	2023-01-04	—	—	EP	disclosed
EP-3670506-B1	THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS	INCYTE HOLDINGS CORP (US)	2023-01-04	—	—	EP	disclosed
US-11229631-B2	Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors	INCYTE CORPORATION (US)	2022-01-25	—	—	US	disclosed
US-11229631-B2	Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors	INCYTE CORPORATION (US)	2022-01-25	—	—	US	disclosed
US-20200405702-A1	THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS	INCYTE CORPORATION	2020-12-31	—	—	US	disclosed
US-20200405702-A1	THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS	INCYTE CORPORATION	2020-12-31	—	—	US	disclosed
US-10828290-B2	Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors	INCYTE CORPORATION (US)	2020-11-10	—	—	US	disclosed
US-10828290-B2	Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors	INCYTE CORPORATION (US)	2020-11-10	—	—	US	disclosed
WO-2012120415-A1	TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS	NOVARTIS AG (CH)	2012-09-13	—	—	WO	disclosed
WO-2012120415-A1	TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS	NOVARTIS AG (CH)	2012-09-13	—	—	WO	disclosed
US-20120225061-A1	TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS	NOVARTIS VACCINES AND DIAGNOSTICS, INC.	2012-09-06	—	—	US	disclosed
US-20120225061-A1	TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS	NOVARTIS VACCINES AND DIAGNOSTICS, INC.	2012-09-06	—	—	US	disclosed
US-20120225062-A1	NOVEL KINASE INHIBITORS	NOVARTIS VACCINES AND DIAGNOSTICS, INC.	2012-09-06	—	—	US	disclosed
US-20120225061-A1	TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS	NOVARTIS VACCINES AND DIAGNOSTICS, INC.	2012-09-06	—	—	US	disclosed
US-20120225062-A1	NOVEL KINASE INHIBITORS	NOVARTIS VACCINES AND DIAGNOSTICS, INC.	2012-09-06	—	—	US	disclosed
US-20120225062-A1	NOVEL KINASE INHIBITORS	NOVARTIS VACCINES AND DIAGNOSTICS, INC.	2012-09-06	—	—	US	disclosed
WO-2012004217-A1	CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS	NOVARTIS AG (CH)	2012-01-12	—	—	WO	disclosed
WO-2012004217-A1	CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS	NOVARTIS AG (CH)	2012-01-12	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20120225062-A1	NOVEL KINASE INHIBITORS	PIM1, PIM2, PIM3	PIM1 1/4885PIM3 3/4885PIM2 2/4885
US-20200405702-A1	THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS	PIM2, PIM1, PIM3	PIM1 2/4885PIM3 3/4885PIM2 1/4885
US-11229631-B2	Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors	PIM2, PIM1, PIM3	PIM1 2/4885PIM3 3/4885PIM2 1/4885
US-10828290-B2	Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors	PIM2, PIM1, PIM3	PIM1 2/4885PIM3 3/4885PIM2 1/4885
US-20120225061-A1	TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS	PIM1, PIM2, PIM3	PIM1 1/4885PIM3 3/4885PIM2 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.