Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | CTSC | P53634 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGAV | P06756 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL2586200 | 0.94 | SLC7A5 (0.35) | CYP3A4SLC7A5CTSCCYP1A2 | |
| D-Histidine SCHEMBL11606906 | 0.94 | SLC7A5 (0.35) | CYP3A4SLC7A5CTSCCYP1A2 | |
| Histidine SCHEMBL27902238 | 0.94 | SLC7A5 (0.35) | CYP3A4SLC7A5CTSCCYP1A2 | |
| Histidine SCHEMBL2586203 | 0.94 | SLC7A5 (0.35) | CYP3A4SLC7A5CTSCCYP1A2 | |
| Histidine SCHEMBL5583260 | 0.93 | CYP3A4 (0.31) | CYP3A4SLC7A5CTSCCYP1A2 | |
| Histidine SCHEMBL3490081 | 0.93 | CYP3A4 (0.32) | CYP3A4SLC7A5CTSCCYP1A2 | |
| Histidine SCHEMBL3088582 | 0.93 | CYP3A4 (0.32) | CYP3A4SLC7A5CTSCCYP1A2 | |
| Histidine SCHEMBL1675273 | 0.93 | CYP3A4 (0.32) | CYP3A4SLC7A5CTSCCYP1A2 | |
| Histidine SCHEMBL790243 | 0.93 | CYP3A4 (0.32) | CYP3A4SLC7A5CTSCCYP1A2 | |
| Histidine SCHEMBL790244 | 0.93 | CYP3A4 (0.32) | CYP3A4SLC7A5CTSCCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180187269-A1 | COMPOSITIONS, METHODS AND KITS FOR THE DIAGNOSIS OF CARRIERS OF MUTATIONS IN THE BRCA1 AND BRCA2 GENES AND EARLY DIAGNOSIS OF CANCEROUS DISORDERS ASSOCIATED WITH MUTATIONS IN BRCA1 AND BRCA2 GENES | HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED (IL) | 2018-07-05 | — | — | US | disclosed |
| US-20150354014-A1 | Compositions, methods and kits for diagnosis of carriers of mutations in the BRCA1 and BRCA2 genes and early diagnosis of cancerous disorders associated with mutations in BRCA1 and BRCA 2 genes | HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED (IL) | 2015-12-10 | — | — | US | disclosed |
| US-20100267569-A1 | Compositions, methods and kits for the diagnosis of carriers of mutations in the BRCA1 and BRCA2 genes and early diagnosis of cancerous disorders associated with mutations in BRCA1 and BRCA2 genes | HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) | 2010-10-21 | — | — | US | disclosed |
| EP-2176424-A2 | COMPOSITIONS, METHODS AND KITS FOR THE DIAGNOSIS OF CARRIERS OF MUTATIONS IN THE BRCA1 AND BRCA2 GENES AND EARLY DIAGNOSIS OF CANCEROUS DISORDERS ASSOCIATED WITH MUTATIONS IN BRCA1 AND BRCA2 GENES | Hadasit Medical Research Services & Development Ltd. (IL) | 2010-04-21 | — | — | EP | disclosed |
| US-7667099-B2 | Plastid division and related genes and proteins, and methods of use | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2010-02-23 | — | — | US | disclosed |
| WO-2009007958-A2 | COMPOSITIONS, METHODS AND KITS FOR THE DIAGNOSIS OF CARRIERS OF MUTATIONS IN THE BRCA1 AND BRCA2 GENES AND EARLY DIAGNOSIS OF CANCEROUS DISORDERS ASSOCIATED WITH MUTATIONS IN BRCA1 AND BRCA2 GENES | HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. (IL) | 2009-01-15 | — | — | WO | disclosed |
| US-20040139500-A1 | Plastid division and related genes and proteins, and methods of use | THE BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2004-07-15 | — | — | US | disclosed |
| WO-2004001003-A2 | PLASTID DIVISION AND RELATED GENES AND PROTEINS, AND METHODS OF USE | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) | 2003-12-31 | — | — | WO | disclosed |