Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 17/20 | 0.46 |
| ▸ | PIM1 | P11309 | 15/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 15/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL319247 | 0.86 | PIM2 (0.56) | PIM2PIM1PIM3GSK3B | |
| SCHEMBL14892813 | 0.82 | PIM1 (0.64) | PIM2PIM1PIM3GSK3B | |
| SCHEMBL14892459 | 0.82 | PIM1 (0.64) | PIM2PIM1PIM3GSK3B | |
| SCHEMBL14890869 | 0.82 | PIM1 (0.64) | PIM2PIM1PIM3GSK3B | |
| SCHEMBL14891020 | 0.82 | PIM1 (0.64) | PIM2PIM1PIM3GSK3B | |
| SCHEMBL14906141 | 0.81 | CYP3A4 (0.51) | PIM2PIM1PIM3GSK3B | |
| SCHEMBL14906142 | 0.81 | PIM2 (0.52) | PIM2PIM1PIM3GSK3B | |
| SCHEMBL14906150 | 0.80 | PIM2 (0.38) | PIM2PIM1PIM3MAPTGSK3B | |
| SCHEMBL325021 | 0.79 | PIM3 (0.53) | PIM2PIM1PIM3GSK3B | |
| SCHEMBL14892314 | 0.78 | PIM1 (0.77) | PIM2PIM1PIM3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590968-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | Novartis AG (CH) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |