Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318829 | 0.82 | MEN1 (0.40) | KMT2AMEN1ALDH1A1HTTRAB9A | |
| SCHEMBL325128 | 0.77 | MEN1 (0.44) | KMT2AMEN1ALDH1A1HTTRAB9A | |
| SCHEMBL319324 | 0.75 | MEN1 (0.39) | KMT2AMEN1ALDH1A1HTTRAB9A | |
| SCHEMBL793501 | 0.75 | MEN1 (0.51) | KMT2AMEN1ALDH1A1HTTRAB9A | |
| SCHEMBL319114 | 0.74 | KMT2A (0.46) | KMT2AMEN1ALDH1A1HTTRAB9A | |
| SCHEMBL320543 | 0.74 | KMT2A (0.40) | KMT2AMEN1ALDH1A1HTTRAB9A | |
| SCHEMBL1910806 | 0.74 | MEN1 (0.38) | KMT2AMEN1ALDH1A1HTTRAB9A | |
| SCHEMBL319433 | 0.74 | MEN1 (0.38) | KMT2AMEN1ALDH1A1HTTRAB9A | |
| SCHEMBL1910793 | 0.73 | MEN1 (0.38) | KMT2AMEN1ALDH1A1HTTRAB9A | |
| SCHEMBL319060 | 0.72 | MEN1 (0.39) | KMT2AMEN1ALDH1A1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590968-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | Novartis AG (CH) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |