Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3202814 | 0.95 | HRH3 (1.00) | HRH3ADRA2AADRA1DCYP1A2CYP2D6 | |
| SCHEMBL13486634 | 0.89 | HRH3 (0.79) | HRH3ADRA2AADRA1D | |
| SCHEMBL3208873 | 0.84 | HRH3 (0.72) | HRH3 | |
| SCHEMBL13486632 | 0.82 | HRH3 (0.70) | HRH3ADRA2AADRA1D | |
| SCHEMBL3190620 | 0.82 | HRH3 (0.74) | HRH3ADRA2AADRA1DCYP1A2CYP2D6 | |
| SCHEMBL3208630 | 0.82 | HRH3 (0.69) | HRH3ADRA2AADRA1D | |
| SCHEMBL3193177 | 0.81 | HRH3 (1.00) | HRH3ADRA2AADRA1DCYP1A2CYP2D6 | |
| SCHEMBL3204557 | 0.81 | HRH3 (1.00) | HRH3 | |
| SCHEMBL3192212 | 0.81 | HRH3 (1.00) | HRH3ADRA2AADRA1DCYP1A2CYP2D6 | |
| SCHEMBL3193150 | 0.80 | HRH3 (1.00) | HRH3ADRA2AADRA1DCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009152071-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY (US) | 2009-12-17 | — | — | WO | claimed |
| US-20100035929-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY | 2010-02-11 | — | — | US | disclosed |
| US-20100035929-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY | 2010-02-11 | — | — | US | disclosed |
| US-20100035929-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY | 2010-02-11 | — | — | US | disclosed |
| WO-2009152071-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY (US) | 2009-12-17 | — | — | WO | disclosed |
| WO-2009152071-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY (US) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035929-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | HRH3, HRH4, HRH1 | HRH3 1/4885ADRA2A 252/4885ADRA1D 437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.