Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I3 | Q14994 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.34 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901326 | 0.92 | CDK5 (0.40) | NR1I3CDK5CDK5R1GRIN1GRIN2B | |
| SCHEMBL332530 | 0.92 | CDK5 (0.40) | NR1I3CDK5CDK5R1GRIN1GRIN2B | |
| SCHEMBL3825 | 0.92 | CDK5 (0.40) | NR1I3CDK5CDK5R1GRIN1GRIN2B | |
| Water SCHEMBL3935755 | 0.91 | CDK5 (0.39) | NR1I3CDK5CDK5R1GRIN1GRIN2B | |
| SCHEMBL789094 | 0.91 | CDK5 (0.39) | NR1I3CDK5CDK5R1GRIN1GRIN2B | |
| Water SCHEMBL1070875 | 0.91 | CDK5 (0.39) | NR1I3CDK5CDK5R1GRIN1GRIN2B | |
| Water SCHEMBL1888091 | 0.91 | CDK5 (0.39) | NR1I3CDK5CDK5R1GRIN1GRIN2B | |
| Ammonia Solution, Strong SCHEMBL2074263 | 0.91 | CDK5 (0.39) | NR1I3CDK5CDK5R1GRIN1GRIN2B | |
| SCHEMBL17856475 | 0.90 | NR1I3 (0.40) | NR1I3CDK5CDK5R1GRIN1GRIN2B | |
| Ether SCHEMBL2165966 | 0.89 | CDK5 (0.35) | NR1I3CDK5CDK5R1GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101648973-A | Water-soluble taxane and preparation method thereof | YOUMAO QI | 2010-02-17 | — | — | CN | claimed |
| EP-1370541-B1 | METHOD OF PREPARATION OF PACLITAXEL (TAXOL) USING 3-(ALK-2-YNYLOXY) CARBONYL-5-OXAZOLIDINE CARBOXYLIC ACID | DABUR INDIA LTD (IN) | 2006-11-02 | — | — | EP | claimed |
| EP-1370541-A1 | METHOD OF PREPARATION OF PACLITAXEL (TAXOL) USING 3-(ALK-2-YNYLOXY) CARBONYL-5-OXAZOLIDINE CARBOXYLIC ACID | Dabur India Limited (IN) | 2003-12-17 | — | — | EP | claimed |
| US-20030013888-A1 | METHOD OF PREPARATION OF PACLITAXEL (TAXOL) USING 3-(ALK-2-YNYLOXY) CARBONYL-5-OXAZOLIDINE CARBOXYLIC ACID | DABUR PHARMA LIMITED (IN) | 2003-01-16 | — | — | US | claimed |
| US-6506905-B1 | Taxol intermediates | DABUR INDIA LIMITED (IN) | 2003-01-14 | — | — | US | claimed |
| WO-2002066448-A1 | METHOD OF PREPARATION OF PACLITAXEL (TAXOL) USING 3-(ALK-2-YNYLOXY) CARBONYL-5-OXAZOLIDINE CARBOXYLIC ACID | DABUR INDIA LIMITED (IN) | 2002-08-29 | — | — | WO | claimed |
| CN-117999304-A | Hydrophobic drug polymer micelle and preparation method thereof | 南京再明医药有限公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-104822262-A | Non-aqueous taxane nanodispersion formulations and methods of use thereof | TEIKOKU PHARMA USA INC | 2015-08-05 | — | — | CN | disclosed |
| CN-101648973-B | Water-soluble taxane and preparation method thereof | YOUMAO QI | 2012-05-30 | — | — | CN | disclosed |
| CN-101648973-A | Water-soluble taxane and preparation method thereof | YOUMAO QI | 2010-02-17 | — | — | CN | disclosed |
| US-20100035977-A1 | TWO-COMPONENT TAXANE CONTAINING PHARMACEUTICAL COMPOSITION | KYSILKA VLADIMIR | 2010-02-11 | — | — | US | disclosed |
| EP-2124929-A1 | A TWO-COMPONENT TAXANE CONTAINING PHARMACEUTICAL COMPOSITION | Heaton A.S. (CZ) | 2009-12-02 | — | — | EP | disclosed |
| CN-100483128-C | Solid phase extraction kit filled with HP20 resin and methods employed of the same | UNIV SHANGHAI JIAOTONG (CN) | 2009-04-29 | — | — | CN | disclosed |
| US-6506905-B1 | Taxol intermediates | DABUR INDIA LIMITED (IN) | 2003-01-14 | — | — | US | disclosed |
| US-20020168745-A1 | Protein for use in the generation of taxol and taxoids for use in the treatment of cancer | WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION | 2002-11-14 | — | — | US | disclosed |
| US-20020138859-A1 | Transacylases of the paclitaxel biosynthetic pathway | WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION | 2002-09-26 | — | — | US | disclosed |
| WO-2002066448-A1 | METHOD OF PREPARATION OF PACLITAXEL (TAXOL) USING 3-(ALK-2-YNYLOXY) CARBONYL-5-OXAZOLIDINE CARBOXYLIC ACID | DABUR INDIA LIMITED (IN) | 2002-08-29 | — | — | WO | disclosed |
| EP-1220930-A2 | TRANSACYLASES OF THE PACLITAXEL BIOSYNTHETIC PATHWAY | WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2002-07-10 | — | — | EP | disclosed |
| US-6287835-B1 | MOLECULAR HYBRIDIZATION; GENE EXPRESSION, GENETIC ENGINEERING | WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION | 2001-09-11 | — | — | US | disclosed |
| WO-2001023586-A2 | TRANSACYLASES OF THE PACLITAXEL BIOSYNTHETIC PATHWAY | WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2001-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013888-A1 | METHOD OF PREPARATION OF PACLITAXEL (TAXOL) USING 3-(ALK-2-YNYLOXY) CARBONYL-5-OXAZOLIDINE CARBOXYLIC ACID | ALK, AHR, PDGFRA | NR1I3 1164/4885CDK5 1265/4885CDK5R1 2017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.