Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3130998 | 0.93 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CEPHX2 | |
| SCHEMBL3131295 | 0.91 | PDE4A (0.44) | PDE4APDE4DPDE4BPDE4CEPHX2 | |
| SCHEMBL4194617 | 0.88 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL1157312 | 0.87 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4CGAA | |
| SCHEMBL3126414 | 0.87 | PDE4B (0.51) | PDE4APDE4DPDE4BPDE4CEPHX2 | |
| SCHEMBL3121037 | 0.86 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CEPHX2 | |
| SCHEMBL1157778 | 0.85 | PDE4A (0.57) | PDE4APDE4DPDE4BPDE4CEPHX2 | |
| SCHEMBL1157639 | 0.84 | PDE4B (0.54) | PDE4APDE4DPDE4BPDE4CEPHX2 | |
| SCHEMBL1157624 | 0.84 | PDE4A (0.57) | PDE4APDE4DPDE4BPDE4CUSP2 | |
| SCHEMBL4195860 | 0.83 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4CEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE3B | PDE4A 1/4885PDE4D 9/4885PDE4B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.