⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3370950 | 0.93 | — | — | |
| SCHEMBL15019333 | 0.85 | — | — | |
| SCHEMBL8151949 | 0.78 | EPHX1 (0.41) | — | |
| SCHEMBL4442007 | 0.77 | — | — | |
| SCHEMBL22747454 | 0.77 | — | — | |
| SCHEMBL4410177 | 0.77 | — | — | |
| SCHEMBL31673078 | 0.77 | — | — | |
| SCHEMBL28302428 | 0.76 | HPGD (0.35) | — | |
| SCHEMBL10923372 | 0.75 | KMT2A (0.41) | — | |
| SCHEMBL1635831 | 0.74 | KMT2A (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 238 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11958861-B2 | Spirocyclic lactams as JAK2 V617F inhibitors | INCYTE CORPORATION (US) | 2024-04-16 | — | — | US | claimed |
| EP-4298099-A1 | SPIROCYCLIC LACTAMS AS JAK2 V617F INHIBITORS | Incyte Corporation (US) | 2024-01-03 | — | — | EP | claimed |
| US-11834470-B2 | 4-thioribose NAD analogues and methods of synthesizing and using the same | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2023-12-05 | — | — | US | claimed |
| US-20230174496-A1 | Synthesis of Vinylic Protected Alcohol Intermediates | AMGEN INC. (US) | 2023-06-08 | — | — | US | claimed |
| US-20230167130-A1 | Ring Closing Synthesis of Macrocyclic MCL-1 Inhibitor Intermediates | AMGEN INC. (US) | 2023-06-01 | — | — | US | claimed |
| EP-4146634-A1 | SYNTHESIS OF VINYL CYCLOBUTYL INTERMEDIATES | Amgen Inc. (US) | 2023-03-15 | — | — | EP | claimed |
| EP-4146638-A1 | RING CLOSING SYNTHESIS OF MACROCYCLIC MCL-1 INHIBITOR INTERMEDIATES | Amgen Inc. (US) | 2023-03-15 | — | — | EP | claimed |
| EP-4146636-A1 | SYNTHESIS OF VINYLIC PROTECTED ALCOHOL INTERMEDIATES | Amgen Inc. (US) | 2023-03-15 | — | — | EP | claimed |
| CN-115485269-A | Ring-closure synthesis of macrocyclic MCL-1 inhibitor intermediates | 安进公司 | 2022-12-16 | — | — | CN | claimed |
| CN-115485267-A | Synthesis of vinylcyclobutyl intermediates | 安进公司 | 2022-12-16 | — | — | CN | claimed |
| WO-2020073026-A1 | 4-THIORIBOSE NAD ANALOGUES AND METHODS OF SYNTHESIZING AND USING THE SAME | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2020-04-09 | — | — | WO | claimed |
| WO-2019152081-A1 | BUGPHOBIC AND ICEPHOBIC COMPOSITIONS WITH FLUID ADDITIVES | HRL LABORATORIES, LLC (US) | 2019-08-08 | — | — | WO | claimed |
| EP-3464315-A1 | METHODS FOR THE PREPARATION OF DEOXYCHOLIC ACID, AND INTERMEDIATES USEFUL IN THE PREPARATION OF DEOXYCHOLIC ACID | Bionice, S.L.U. (ES) | 2019-04-10 | — | — | EP | claimed |
| US-20190023910-A1 | BUGPHOBIC AND ICEPHOBIC COMPOSITIONS WITH FLUID ADDITIVES | HRL LABORATORIES, LLC | 2019-01-24 | — | — | US | claimed |
| US-20180305395-A1 | METHODS FOR THE PREPARATION OF DEOXYCHOLIC ACID, AND INTERMEDIATES USEFUL IN THE PREPARATION OF DEOXYCHOLIC ACID | CRYSTAL PHARMA S.A.U. (ES) | 2018-10-25 | — | — | US | claimed |
| WO-2017211820-A1 | METHODS FOR THE PREPARATION OF DEOXYCHOLIC ACID, AND INTERMEDIATES USEFUL IN THE PREPARATION OF DEOXYCHOLIC ACID | BIONICE, S.L.U. (ES) | 2017-12-14 | — | — | WO | claimed |
| US-20100041905-A1 | Process for the Preparation of Substituted 2-Acetylamino-Alkoxyphenyl | ASTRAZENECA AB (SE) | 2010-02-18 | — | — | US | claimed |
| EP-2044045-A2 | A PROCESS FOR THE PREPARATION OF SUBSTITUTED 2-ACETYLAMINO-ALKOXYPHENYL | AstraZeneca AB (SE) | 2009-04-08 | — | — | EP | claimed |
| WO-2008010764-A2 | A PROCESS FOR THE PREPARATION OF SUBSTITUTED 2-ACETYLAMINO-ALKOXYPHENYL | ASTRAZENECA AB (SE) | 2008-01-24 | — | — | WO | claimed |
| US-20040121399-A1 | Substrate bound linker molecules for the construction of biomolecule microarrays | INTERNATIONAL BUSINESS MACHINES CORPORATION | 2004-06-24 | — | — | US | claimed |