SCHEMBL3206747

SCHEMBL3206747

Nc1cc(OCC2CCCCC2)nc(Nc2ccc(S(N)(=O)=O)cc2)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 18/20 1.00
CDK1 P06493 11/20 1.00
CCNA2 P20248 11/20 1.00
CCNA1 P78396 9/20 1.00
GSK3B P49841 2/20 0.61
CCNB1 P14635 8/20 0.61
CCNT1 O60563 5/20 0.61
CDK7 P50613 5/20 0.61
CDK9 P50750 5/20 0.61
CCNH P51946 5/20 0.61
CDK5 Q00535 4/20 0.61
CCNB2 O95067 4/20 0.60
CCNB3 Q8WWL7 4/20 0.60
ROCK2 O75116 1/20 0.60
CDK4 P11802 1/20 0.60
CCND1 P24385 1/20 0.60
CCNE1 P24864 1/20 0.60
MNAT1 P51948 1/20 0.60
DYRK1A Q13627 1/20 0.60
CDK5R1 Q15078 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12589617 0.83 CDK2 (1.00) CDK2CDK1CCNA2CCNA1CCNB1
SCHEMBL14367532 0.76 CDK2 (1.00) CDK2CDK1CCNA2CCNA1GSK3B
SCHEMBL12589612 0.76 CDK2 (0.75) CDK2CDK1CCNA2CCNA1GSK3B
SCHEMBL4264549 0.75 CDK2 (1.00) CDK2CDK1CCNA2CCNA1GSK3B
SCHEMBL2170816 0.75 CDK2 (1.00) CDK2CDK1CCNA2CCNA1GSK3B
SCHEMBL30123470 0.75 CDK2 (1.00) CDK2CDK1CCNA2CCNA1GSK3B
SCHEMBL4360432 0.75 CDK2 (0.60) CDK2CDK1CCNA2CCNA1GSK3B
SCHEMBL24477949 0.74 CDK2 (0.66) CDK2CDK1CCNA2CCNA1GSK3B
SCHEMBL6798577 0.74 CDK2 (0.73) CDK2CDK1CCNA2CCNA1GSK3B
SCHEMBL24477842 0.73 CDK2 (0.64) CDK2CDK1CCNA2CCNA1GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010017312-A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS OF THE BOWEL THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2010-02-11 WO claimed
US-20100035852-A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS OF THE BOWEL THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2010-02-11 US claimed