Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL17272919 | 1.00 | TDP1 (0.52) | TDP1MAPK1HSD17B10TSHRLMNA | |
| SCHEMBL7615057 | 0.98 | TDP1 (0.54) | TDP1MAPK1HSD17B10TSHRLMNA | |
| SCHEMBL3185056 | 0.98 | TDP1 (0.54) | TDP1MAPK1HSD17B10TSHRLMNA | |
| SCHEMBL3193159 | 0.98 | TDP1 (0.54) | TDP1MAPK1HSD17B10TSHRLMNA | |
| SCHEMBL3192072 | 0.98 | TDP1 (0.54) | TDP1MAPK1HSD17B10TSHRLMNA | |
| SCHEMBL268561 | 0.98 | TDP1 (0.54) | TDP1MAPK1HSD17B10TSHRLMNA | |
| SCHEMBL15029 | 0.98 | TDP1 (0.54) | TDP1MAPK1HSD17B10TSHRLMNA | |
| SCHEMBL18322329 | 0.98 | TDP1 (0.54) | TDP1MAPK1HSD17B10TSHRLMNA | |
| SCHEMBL15169 | 0.98 | TDP1 (0.54) | TDP1MAPK1HSD17B10TSHRLMNA | |
| SCHEMBL648718 | 0.98 | TDP1 (0.54) | TDP1MAPK1HSD17B10TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011112923-A9 | POLYURETHANE POLYMERS COMPRISING COPOLYESTER POLYOLS HAVING REPEAT UNITS DERIVED FROM BIOBASED ω-HYDROXYFATTY ACIDS | SYNTHEZYME LLC (US) | 2012-01-12 | — | — | WO | claimed |
| CN-114450323-A | Low free polyurethane prepolymer compositions | 朗盛公司 | 2022-05-06 | — | — | CN | disclosed |
| US-5976514-A | INCLUDING A VOLATILE, NONPOLAR HYDROCARBON LIQUID HAVING A SOLUBILITY PARAMETER OF LESS THAN ABOUT 7.5 (CAL/CM.3)0.5 AND A VAPOR PRESSURE AS MEASURED AT 25 DEGREES C. OF FROM 0.01 MMHG TO ABOUT 6.0 MMHG. | PROCTER & GAMBLE COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0773978-A1 | CLEANING OR SCOURING COMPOSITIONS, AND PREPARATIONS CONTAINING THEM | STE INDUSTRIELLE ET COMMERCIALE DU RHONE-SINCORA (FR) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996004342-A1 | CLEANING OR SCOURING COMPOSITIONS, AND PREPARATIONS CONTAINING THEM | STE INDUSTRIELLE ET COMMERCIALE DU RHONE - SINCORA (FR) | 1996-02-15 | — | — | WO | disclosed |