Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | CASP2 | P42575 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3542786 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2CNR2PARP1FAAHNAAA | |
| SCHEMBL1632308 | 0.79 | SMN1; SMN2 (0.39) | SMN1; SMN2CNR2PARP1FAAHNAAA | |
| SCHEMBL17162718 | 0.79 | SMN1; SMN2 (0.39) | SMN1; SMN2CNR2PARP1FAAHNAAA | |
| SCHEMBL3212643 | 0.77 | SMN1; SMN2 (0.39) | SMN1; SMN2CNR2PARP1ALDH1A1TSHR | |
| SCHEMBL10734073 | 0.77 | SMN1; SMN2 (0.37) | SMN1; SMN2CNR2PARP1 | |
| SCHEMBL13223504 | 0.76 | SMN1; SMN2 (0.38) | SMN1; SMN2CNR2PARP1TSHRNPSR1 | |
| SCHEMBL1583189 | 0.75 | POLB (0.41) | SMN1; SMN2CNR2TSHRPOLBMEN1 | |
| SCHEMBL12003684 | 0.74 | CACNA2D1 (0.44) | SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL10738631 | 0.73 | SMN1; SMN2 (0.39) | SMN1; SMN2CNR2PARP1 | |
| SCHEMBL12003738 | 0.71 | CACNA1B (0.44) | SMN1; SMN2CNR2PARP1FAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010019930-A1 | UREA DERIVATIVES AS INHIBITORS OF MAP KINASES | LOCUS PHARMACEUTICALS, INC. (US) | 2010-02-18 | — | — | WO | disclosed |
| US-20100041642-A1 | UREA INHIBITORS OF MAP KINASES | LOCUS PHARMACEUTICALS, INC. (US) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041642-A1 | UREA INHIBITORS OF MAP KINASES | MAP4K2, MAP3K1, MAP3K20 | SMN1; SMN2 4267/4885CNR2 4569/4885PARP1 2990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.