⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL800202 | 0.61 | — | — | |
| SCHEMBL9942041 | 0.50 | — | — | |
| SCHEMBL514415 | 0.50 | — | — | |
| SCHEMBL667144 | 0.50 | — | — | |
| SCHEMBL797019 | 0.50 | — | — | |
| SCHEMBL7777525 | 0.50 | — | — | |
| SCHEMBL13944882 | 0.50 | — | — | |
| SCHEMBL10167397 | 0.50 | — | — | |
| SCHEMBL13815301 | 0.50 | — | — | |
| SCHEMBL17035571 | 0.50 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106632501-A | Rhodium-diphosphine ligand tetrafluoroborate and preparation method thereof | 重庆博腾制药科技股份有限公司 | 2017-05-10 | — | — | CN | claimed |
| EP-0553778-B1 | Asymmetric hydrogenation | HOFFMANN LA ROCHE (CH) | 2001-12-12 | — | — | EP | claimed |
| EP-0574783-B1 | Asymmetric hydrogenation | HOFFMANN LA ROCHE (CH) | 1999-10-06 | — | — | EP | claimed |
| EP-0562450-B1 | Mixtures of decyl alcohols, phthalic acid esters obtained from these and their application as plasticisers | CELANESE GMBH (DE) | 1998-12-09 | — | — | EP | claimed |
| EP-0571819-B1 | Sulfonated 2,2'-bis(diphenylphosphinomethyl)-1,1'-binaphthalenes, process for their preparation and their use in a process for the hydroformylation of olefinic unsaturated compounds | CELANESE GMBH (DE) | 1998-11-11 | — | — | EP | claimed |
| US-5514805-A | ASSYMETRIC HYDROGENATION OF A PYRIDINECARBONYL COMPOUND, RHODIUM PHOSPHINE CATALYST | HOFFMANN-LA ROCHE INC. (US) | 1996-05-07 | — | — | US | claimed |
| US-5374727-A | Using rhodium-diphosphine complex as hydrogenation catalyst | HOFFMANN-LA ROCHE INC. (US) | 1994-12-20 | — | — | US | claimed |
| EP-0257411-B1 | METHOD FOR THE PRODUCTION OF OPTICALLY ACTIVE ENAMINES OR THE CORRESPONDING ALDEHYDES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-25 | — | — | EP | claimed |
| US-5142063-A | For hydrogenation of alpha-beta unsaturated acids and esters alpha-meto lactones and alpha-keto acids or esters | HOFFMANN-LA ROCHE, INC. (US) | 1992-08-25 | — | — | US | claimed |
| EP-0218970-B1 | CHIRAL RHODIUM-DIPHOSPHINE COMPLEXES FOR ASYMMETRICAL HYDROGENATION | F. HOFFMANN-LA ROCHE AG (CH) | 1992-06-17 | — | — | EP | claimed |
| US-5110955-A | Chiral rhodium or palladium-diphosphine catalyst | HOFFMANN-LA ROCHE INC. (US) | 1992-05-05 | — | — | US | claimed |
| EP-0392389-A2 | Process for the preparation of vinyl compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1990-10-17 | — | — | EP | claimed |
| EP-0158875-B1 | CHIRAL-RHODIUM-DIPHOSPHINE COMPLEXES FOR ASYMETRIC HYDROGENATIONS | F. HOFFMANN-LA ROCHE AG (CH) | 1989-12-13 | — | — | EP | claimed |
| US-4861890-A | Isomerization | HOFFMANN-LA ROCHE INC. (US) | 1989-08-29 | — | — | US | claimed |
| US-4652657-A | Chiral rhodium-diphosphine complexes | HOFFMANN-LA ROCHE INC. (US) | 1987-03-24 | — | — | US | claimed |
| JP-2292277-A | — | — | None | — | — | JP | disclosed |
| JP-6065240-A | — | — | None | — | — | JP | disclosed |
| US-4216331-A | Use of chiral rhodium-diphosphine catalyst capable of catalytic reduction of a tetramisole precursor to give a significant excess of the desired S-(-) isomer levamisole | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |
| US-4166824-A | Chiral rhodium-diphosphine catalyst capable of catalytic reduction of a tetramisole precursor to give a significant excess of the desired S-(-)isomer, levamisole | AMERICAN CYANAMID COMPANY (US) | 1979-09-04 | — | — | US | disclosed |
| US-4166824-A | Chiral rhodium-diphosphine catalyst capable of catalytic reduction of a tetramisole precursor to give a significant excess of the desired S-(-)isomer, levamisole | AMERICAN CYANAMID COMPANY (US) | 1979-09-04 | — | — | US | disclosed |