Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 16/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 8/20 | 0.42 |
| ▸ | CDK1 | P06493 | 4/20 | 0.39 |
| ▸ | PRKACA | P17612 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | INSR | P06213 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | ITK | Q08881 | 2/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3227011 | 0.78 | CDC7 (0.41) | CDC7DBF4CHEK1MAP2K1DYRK1A | |
| SCHEMBL2073846 | 0.71 | HTR2A (0.38) | — | |
| SCHEMBL27750352 | 0.69 | OPRL1 (0.46) | CDC7DBF4CDK1PRKACAGSK3B | |
| SCHEMBL3230396 | 0.68 | OPRL1 (0.42) | CDC7DBF4CDK1PRKACAGSK3B | |
| SCHEMBL3229742 | 0.68 | CDC7 (0.44) | CDC7DBF4CDK1PRKACAGSK3B | |
| SCHEMBL19826342 | 0.66 | AXL (0.44) | CDC7CDK1PRKACAGSK3BHIPK2 | |
| SCHEMBL12523949 | 0.66 | AXL (0.44) | CDC7CDK1PRKACAGSK3BHIPK2 | |
| SCHEMBL27590571 | 0.64 | AXL (0.51) | CDC7PRKACAGSK3BHIPK2IRAK4 | |
| SCHEMBL820352 | 0.64 | AXL (0.55) | CDC7PRKACAGSK3BHIPK2IRAK4 | |
| SCHEMBL30068926 | 0.64 | AXL (0.55) | CDC7PRKACAGSK3BHIPK2IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056499-A1 | 3-AMINO-1-ARYLPROPYL AZAINDOLES AND USES THEREOF | GREENHOUSE ROBERT | 2010-03-04 | — | — | US | disclosed |
| US-20100056499-A1 | 3-AMINO-1-ARYLPROPYL AZAINDOLES AND USES THEREOF | GREENHOUSE ROBERT | 2010-03-04 | — | — | US | disclosed |
| US-20100056499-A1 | 3-AMINO-1-ARYLPROPYL AZAINDOLES AND USES THEREOF | GREENHOUSE ROBERT | 2010-03-04 | — | — | US | disclosed |
| US-7638517-B2 | 3-Amino-1-arylpropyl azaindoles and uses thereof | ROCHE PALO ALTO LLC (US) | 2009-12-29 | — | — | US | disclosed |
| US-7638517-B2 | 3-Amino-1-arylpropyl azaindoles and uses thereof | ROCHE PALO ALTO LLC (US) | 2009-12-29 | — | — | US | disclosed |
| US-7638517-B2 | 3-Amino-1-arylpropyl azaindoles and uses thereof | ROCHE PALO ALTO LLC (US) | 2009-12-29 | — | — | US | disclosed |
| EP-1957488-B1 | 3-AMINO-2-ARYLPROPYL AZAINDOLES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2009-09-09 | — | — | EP | disclosed |
| EP-1957488-A1 | 3-AMINO-2-ARYLPROPYL AZAINDOLES AND USES THEREOF | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007062998-A1 | 3-AMINO-2-ARYLPROPYL AZAINDOLES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |
| WO-2007062998-A1 | 3-AMINO-2-ARYLPROPYL AZAINDOLES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |
| US-20070123535-A1 | 3-Amino-1-arylpropyl azaindoles and uses thereof | ROCHE PALO ALTO LLC | 2007-05-31 | — | — | US | disclosed |
| US-20070123535-A1 | 3-Amino-1-arylpropyl azaindoles and uses thereof | ROCHE PALO ALTO LLC | 2007-05-31 | — | — | US | disclosed |
| US-20070123535-A1 | 3-Amino-1-arylpropyl azaindoles and uses thereof | ROCHE PALO ALTO LLC | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123535-A1 | 3-Amino-1-arylpropyl azaindoles and uses thereof | CNKSR1, AR, CYP3A43 | CDC7 2146/4885DBF4 3655/4885CDK1 267/4885 |
| US-20100056499-A1 | 3-AMINO-1-ARYLPROPYL AZAINDOLES AND USES THEREOF | CNKSR1, AR, CYP3A43 | CDC7 2146/4885DBF4 3655/4885CDK1 267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.