Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C8 | P10632 | 6/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.32 |
| ▸ | AXL | P30530 | 3/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2464803 | 0.91 | CYP2C8 (0.37) | CYP2C8KCNH2CYP3A4PDE2APDE10A | |
| SCHEMBL9911917 | 0.80 | CYP2C8 (0.37) | CYP2C8KCNH2CYP3A4PDE2APDE10A | |
| SCHEMBL2464594 | 0.80 | CYP2C8 (0.38) | CYP2C8KCNH2CYP3A4PDE2ANR1I2 | |
| SCHEMBL2469426 | 0.79 | CYP2C8 (0.48) | CYP2C8KCNH2CYP3A4PDE2APDE10A | |
| SCHEMBL2464273 | 0.78 | CYP2C8 (0.37) | CYP2C8KCNH2CYP3A4PDE2APDE10A | |
| SCHEMBL2997319 | 0.78 | CYP2C8 (0.42) | CYP2C8KCNH2CYP3A4NR1I2CSNK1D | |
| SCHEMBL1918342 | 0.78 | CYP2C8 (0.56) | CYP2C8KCNH2CYP3A4NR1I2 | |
| SCHEMBL2991677 | 0.77 | CYP2C8 (0.46) | CYP2C8KCNH2CYP3A4NR1I2CSNK1D | |
| SCHEMBL9911912 | 0.77 | CYP2C8 (0.49) | CYP2C8KCNH2CYP3A4NR1I2KIT | |
| SCHEMBL1937305 | 0.77 | CYP2C8 (0.37) | CYP2C8KCNH2CYP3A4PDE2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198449-B2 | Compounds for the treatment of hepatitis C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-06-12 | — | — | US | claimed |
| US-20100063068-A1 | Compounds for the Treatment of Hepatitis C | BRISTOL-MYERS SQUIBB COMPANY | 2010-03-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063068-A1 | Compounds for the Treatment of Hepatitis C | HAVCR2, HCCS, SLC10A1 | CYP2C8 168/4885KCNH2 3450/4885CYP3A4 230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.