Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 19/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.80 |
| ▸ | DRD3 | P35462 | 1/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3220372 | 0.95 | P2RY12 (0.91) | P2RY12CYP2C9CYP3A4CHRM2DRD3 | |
| SCHEMBL3226457 | 0.94 | P2RY12 (1.00) | P2RY12CYP2C9CYP3A4CHRM2DRD3 | |
| SCHEMBL3219548 | 0.92 | P2RY12 (0.85) | P2RY12CYP2C9CYP3A4CHRM2DRD3 | |
| SCHEMBL3231186 | 0.92 | P2RY12 (0.88) | P2RY12CYP2C9CYP3A4CHRM2DRD3 | |
| SCHEMBL3226279 | 0.92 | P2RY12 (1.00) | P2RY12CYP2C9CYP3A4CHRM2DRD3 | |
| SCHEMBL3212680 | 0.92 | P2RY12 (0.85) | P2RY12CYP2C9CYP3A4CHRM2DRD3 | |
| SCHEMBL3209585 | 0.92 | P2RY12 (0.84) | P2RY12CYP2C9CYP3A4CHRM2DRD3 | |
| SCHEMBL3217332 | 0.91 | P2RY12 (0.88) | P2RY12CYP2C9CYP3A4CHRM2DRD3 | |
| SCHEMBL3224743 | 0.91 | P2RY12 (0.83) | P2RY12CYP2C9CYP3A4CHRM2DRD3 | |
| SCHEMBL3226367 | 0.91 | P2RY12 (0.85) | P2RY12CYP2C9CYP3A4CHRM2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010005385-A1 | 2-AMINO-6-ALKYL SUBSTITUTED PYRIDINE DERIVATIVES USEFUL AS P2Y12 INHIBITORS 308 | ASTRAZENECA AB (SE) | 2010-01-14 | — | — | WO | claimed |
| WO-2010005385-A1 | 2-AMINO-6-ALKYL SUBSTITUTED PYRIDINE DERIVATIVES USEFUL AS P2Y12 INHIBITORS 308 | ASTRAZENECA AB (SE) | 2010-01-14 | — | — | WO | disclosed |
| WO-2010005385-A1 | 2-AMINO-6-ALKYL SUBSTITUTED PYRIDINE DERIVATIVES USEFUL AS P2Y12 INHIBITORS 308 | ASTRAZENECA AB (SE) | 2010-01-14 | — | — | WO | disclosed |