Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.55 |
| ▸ | CDK1 | P06493 | 5/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.55 |
| ▸ | CDK4 | P11802 | 4/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
| ▸ | CCND1 | P24385 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | CCND3 | P30281 | 1/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.55 |
| ▸ | GSK3A | P49840 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | CDK7 | P50613 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.55 |
| ▸ | CCNH | P51946 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3219960 | 0.90 | MAPK9 (0.62) | CDK2CDK1KCNH2MAPK9CDK4 | |
| SCHEMBL3226725 | 0.90 | MAPK9 (0.62) | CDK2CDK1KCNH2MAPK9CDK4 | |
| SCHEMBL3225468 | 0.85 | CDK2 (0.49) | CDK2CDK1KCNH2MAPK9CDK4 | |
| SCHEMBL3225412 | 0.84 | CDK2 (0.52) | CDK2CDK1KCNH2MAPK9CDK4 | |
| SCHEMBL3221460 | 0.84 | CDK2 (0.54) | CDK2CDK1KCNH2MAPK9CDK4 | |
| SCHEMBL3220132 | 0.83 | CDK2 (0.56) | CDK2CDK1KCNH2MAPK9CDK4 | |
| Lithium Ion SCHEMBL3220139 | 0.82 | CDK2 (0.55) | CDK2CDK1KCNH2MAPK9CDK4 | |
| SCHEMBL4496303 | 0.82 | KCNH2 (0.59) | CDK2CDK1KCNH2MAPK9CDK4 | |
| SCHEMBL4507252 | 0.82 | KCNH2 (0.59) | CDK2CDK1KCNH2MAPK9CDK4 | |
| SCHEMBL3225094 | 0.82 | CDK2 (0.55) | CDK2CDK1KCNH2MAPK9CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063049-A1 | 2-CARBOCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063049-A1 | 2-CARBOCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHBITION OF CELL PROLIFERATION | MKI67, CCNI, CDK2 | CDK2 3/4885CDK1 38/4885KCNH2 2260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.