SCHEMBL322260

SCHEMBL322260

OCCOCC1CC1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4614051 1.00 TSHR (0.47)
SCHEMBL11314262 0.93 TSHR (0.41)
SCHEMBL4592512 0.90
SCHEMBL13500013 0.89 TSHR (0.48)
SCHEMBL7536089 0.87 GBA1 (0.44)
SCHEMBL31601986 0.87 GBA1 (0.44)
SCHEMBL4603376 0.86
SCHEMBL21215385 0.85 MEN1 (0.50)
SCHEMBL19102293 0.85 MEN1 (0.45)
SCHEMBL25957609 0.85 MEN1 (0.44)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1280798-B1 BICYCLIC HETEROCYLCES, MEDICAMENTS CONTAINING SAID COMPOUNDS, THE USE THEREOF AND METHOD FOR PRODUCING THEM BOEHRINGER INGELHEIM PHARMA (DE) 2007-01-03 EP claimed
EP-1315720-B1 BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE, AND METHODS FOR THE PRODUCTION THEREOF BOEHRINGER INGELHEIM PHARMA (DE) 2005-07-06 EP claimed
US-6740651-B2 TREATING PARTICULARLY TUMORAL DISEASES, DISEASES OF THE LUNGS AND RESPIRATORY TRACT. BOEHRINGER INGELHEIM PHARMA KG (DE) 2004-05-25 US claimed
US-6627634-B2 Antitumor agents, treatment of the lungs and respiratory tract BOEHRINGER INGELHEIM PHARMA KG (DE) 2003-09-30 US claimed
US-20020115675-A1 Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2002-08-22 US claimed
US-20010044435-A1 Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2001-11-22 US claimed
EP-0103500-B1 PHENETHYL-1-ALPHA-PHENYL-PIPERIDINE-3-PROPANE-NITRILE DERIVATIVES, THEIR PREPARATION AND THERAPEUTICAL USE SYNTHELABO (FR) 1988-01-13 EP claimed
CN-117980310-A Alkylene derivatives as KRAS inhibitors 尼坎治疗公司 2024-05-03 CN disclosed
CN-108069969-B Nitrogen-containing heterocyclic compound, preparation method, intermediate, pharmaceutical composition and application 南京海璞医药科技有限公司 2020-09-18 CN disclosed
EP-3129344-B1 METHOD FOR PREPARATION OF 4-ALKOXY-1,1,1-TRIFLUOROBUT-3-EN-2- ONES FROM 1,1,1-TRIFLUOROACETONE LONZA AG (CH) 2017-10-18 EP disclosed
US-9663436-B1 Method for preparation of 4-alkoxy-1,1,1-trifluorobut-3-en-2-ones from 1,1,1-trifluoroacetone LONZA LTD (CH) 2017-05-30 US disclosed
US-20170137359-A1 Method For Preparation of 4-Alkoxy-1,1,1-Trifluorobut-3-en-2-ones From 1,1,1-Trifluoroacetone LONZA LTD (CH) 2017-05-18 US disclosed
EP-3129344-A1 METHOD FOR PREPARATION OF 4-ALKOXY-1,1,1-TRIFLUOROBUT-3-EN-2- ONES FROM 1,1,1-TRIFLUOROACETONE Lonza Ltd (CH) 2017-02-15 EP disclosed
EP-0177515-A4 3-AMINOPROPYLOXYPHENYL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. SANDOZ LTD (CH) 1986-09-23 EP disclosed
EP-0177515-A1 3-AMINOPROPYLOXYPHENYL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. SANDOZ LTD (CH) 1986-04-16 EP disclosed
WO-1985004403-A1 3-AMINOPROPYLOXYPHENYL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SANDOZ LTD. (CH) 1985-10-10 WO disclosed
EP-0061379-B1 PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THERAPEUTIC PREPARATIONS SYNTHELABO (FR) 1985-10-02 EP disclosed
US-4481207-A CALCIUM ANTAGONISTS, HYPOTENSIVES SYNTHELABO (FR) 1984-11-06 US disclosed
US-4406907-A Certain 2,5-disubstituted pyridine derivatives producing β-adrenergic blocking action SYNTHELABO (FR) 1983-09-27 US disclosed
US-4401820-A IN THE PRESENCE OF AN ACYCLIC ACID AND AN ALDEHYDE; STABILITY TANABE SEIYAKU CO., LTD. (JP) 1983-08-30 US disclosed