Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.63 |
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3233015 | 0.89 | MEN1 (0.58) | S1PR1MEN1KMT2AEGFRERBB3 | |
| SCHEMBL3229139 | 0.85 | S1PR1 (0.72) | S1PR1MEN1KMT2AEGFRERBB3 | |
| SCHEMBL3221284 | 0.84 | S1PR1 (0.63) | S1PR1EGFRERBB3NPC1RAB9A | |
| SCHEMBL3222703 | 0.81 | NPC1 (0.53) | S1PR1MEN1KMT2AEGFRERBB3 | |
| SCHEMBL3220007 | 0.80 | S1PR1 (0.52) | S1PR1MEN1KMT2AEGFRERBB3 | |
| SCHEMBL3222813 | 0.78 | EGFR (0.64) | S1PR1MEN1KMT2AEGFRERBB3 | |
| SCHEMBL3226154 | 0.77 | S1PR1 (0.61) | S1PR1MEN1KMT2AEGFRERBB3 | |
| SCHEMBL2880368 | 0.77 | S1PR1 (1.00) | S1PR1SMN1; SMN2S1PR3AURKA | |
| SCHEMBL14906228 | 0.77 | S1PR1 (0.76) | S1PR1 | |
| SCHEMBL3234588 | 0.76 | S1PR1 (0.62) | S1PR1NPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | claimed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | claimed |