Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 12/20 | 0.77 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.71 |
| ▸ | TTR | P02766 | 2/20 | 0.71 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.71 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.71 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | ABL1 | P00519 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | BCR | P11274 | 1/20 | 0.71 |
| ▸ | NQO2 | P16083 | 1/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | GFER | P55789 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3222975 | 1.00 | BACE1 (0.77) | BACE1PTGS2MAPTABCB1TTR | |
| SCHEMBL3200543 | 0.95 | BACE1 (0.85) | BACE1PTGS2MAPTABCB1TTR | |
| SCHEMBL3200533 | 0.95 | BACE1 (0.85) | BACE1PTGS2MAPTABCB1TTR | |
| SCHEMBL14864159 | 0.89 | GSK3B (0.87) | BACE1PTGS2MAPTABCB1MEN1 | |
| SCHEMBL3222937 | 0.87 | BACE1 (1.00) | BACE1PTGS2MAPTABCB1TTR | |
| SCHEMBL3222916 | 0.87 | BACE1 (1.00) | BACE1PTGS2MAPTABCB1TTR | |
| SCHEMBL3209220 | 0.87 | BACE1 (0.68) | BACE1PTGS2MAPTABCB1GSK3B | |
| SCHEMBL3209234 | 0.87 | BACE1 (0.68) | BACE1PTGS2MAPTABCB1GSK3B | |
| SCHEMBL3218888 | 0.85 | BACE1 (0.74) | BACE1PTGS2MAPTABCB1RAB9A | |
| SCHEMBL3218904 | 0.85 | BACE1 (0.74) | BACE1PTGS2MAPTABCB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962674-B2 | Curcumin derivative | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2123637-A1 | NOVEL CURCUMIN DERIVATIVE | Tokyo Institute of Technology (JP) | 2009-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | BACE1 1/4885PTGS2 1089/4885MAPT 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.