SCHEMBL3225985

SCHEMBL3225985

NC(=O)c1ccc(Nc2cc(C(=O)Nc3ccc(F)cc3)ncn2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.61
ERBB3 P21860 1/20 0.61
GAK O14976 1/20 0.51
PDGFRB P09619 1/20 0.51
KIT P10721 1/20 0.51
FLT3 P36888 1/20 0.51
MKNK2 Q9HBH9 1/20 0.51
MARK1 Q9P0L2 1/20 0.51
STK17A Q9UEE5 1/20 0.51
ABL1 P00519 2/20 0.48
BCR P11274 2/20 0.48
S1PR1 P21453 4/20 0.48
KDM4E B2RXH2 1/20 0.48
NPC1 O15118 1/20 0.48
MAPT P10636 1/20 0.48
RAB9A P51151 1/20 0.48
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.46
POLB P06746 1/20 0.46
P4HTM Q9NXG6 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3222813 0.91 EGFR (0.64) EGFRERBB3S1PR1NPC1RAB9A
SCHEMBL3225361 0.89 EGFR (0.62) EGFRERBB3S1PR1NPC1RAB9A
SCHEMBL13456856 0.88 EGFR (0.57) EGFRERBB3S1PR1NPC1MAPT
SCHEMBL3218204 0.87 EGFR (0.63) EGFRERBB3ABL1BCRS1PR1
SCHEMBL3228067 0.86 EGFR (0.58) EGFRERBB3S1PR1NPC1RAB9A
SCHEMBL3222525 0.86 EGFR (0.73) EGFRERBB3S1PR1NPC1RAB9A
SCHEMBL3221284 0.86 S1PR1 (0.63) EGFRERBB3S1PR1NPC1RAB9A
SCHEMBL3229185 0.85 EGFR (0.57) EGFRERBB3S1PR1NPC1MAPT
SCHEMBL3225967 0.85 EGFR (0.57) EGFRERBB3S1PR1NPC1RAB9A
SCHEMBL3227860 0.83 EGFR (0.58) EGFRERBB3ABL1BCRS1PR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010020432-A8 COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY BIOMARIN IGA LIMITED (BS) 2010-03-11 WO claimed
WO-2010020432-A2 COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY SUMMIT CORPORATION PLC (GB) 2010-02-25 WO claimed
WO-2010020432-A8 COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY BIOMARIN IGA LIMITED (BS) 2010-03-11 WO disclosed
WO-2010020432-A8 COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY BIOMARIN IGA LIMITED (BS) 2010-03-11 WO disclosed
WO-2010020432-A2 COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY SUMMIT CORPORATION PLC (GB) 2010-02-25 WO disclosed
WO-2010020432-A2 COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY SUMMIT CORPORATION PLC (GB) 2010-02-25 WO disclosed