Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rifampin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.97 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.97 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.97 |
| ▸ | MEN1 | O00255 | 2/20 | 0.97 |
| ▸ | GAA | P10253 | 2/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.97 |
| ▸ | ABCC3 | O15438 | 2/20 | 0.97 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.97 |
| ▸ | ABCC2 | Q92887 | 2/20 | 0.97 |
| ▸ | SLCO2B1 | O94956 | 2/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.97 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.97 |
| ▸ | SLCO1A2 | P46721 | 2/20 | 0.97 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.97 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rifampin SCHEMBL3227173 | 1.00 | MAPT (0.97) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL15472876 | 0.98 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL14252040 | 0.98 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL14922822 | 0.98 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL14927261 | 0.98 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL66289 | 0.98 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL16499164 | 0.98 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL22517710 | 0.98 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL22432205 | 0.98 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL14029509 | 0.98 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557535-B2 | Methods for preparation of platelet rich plasma | INCEPT LLC (US) | 2013-10-15 | — | — | US | disclosed |
| US-20100069613-A1 | IMPLANTABLE MATERIALS AND COMPOSITIONS | INCEPT LLC | 2010-03-18 | — | — | US | disclosed |
| US-7605232-B2 | Hydrogels for protein concentration | INCEPT LLC (US) | 2009-10-20 | — | — | US | disclosed |
| US-20070197776-A1 | Simple, rapid production of fibrin tissue adhesive and drug delivery systems; water removal from blood plasma by absorptive swelling | INCEPT LLC | 2007-08-23 | — | — | US | disclosed |
| US-7211651-B2 | Proteinaceous gels having visualization agents and methods of use thereof | INCEPT LLC (US) | 2007-05-01 | — | — | US | disclosed |
| US-7057019-B2 | Crosslinked albumin hydrogels | INCEPT LLC (US) | 2006-06-06 | — | — | US | disclosed |
| US-6887974-B2 | Crosslinking agents and methods of use | INCEPT LLC (US) | 2005-05-03 | — | — | US | disclosed |
| US-20040002456-A1 | Methods and devices for preparing protein concentrates | INCEPT LLC | 2004-01-01 | — | — | US | disclosed |
| US-20030077272-A1 | Proteinaceous gels having visualization agents and methods of use thereof | INCEPT LLC | 2003-04-24 | — | — | US | disclosed |
| US-20020114775-A1 | Crosslinking agents and methods of use | INCEPT LLC | 2002-08-22 | — | — | US | disclosed |
| WO-1998012274-A1 | METHODS AND DEVICES FOR PREPARING PROTEIN CONCENTRATES | PATHAK CHANDRASHEKAR (US) | 1998-03-26 | — | — | WO | disclosed |