Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27450081 | 0.81 | KDM4E (0.33) | KDM4EHDAC3HDAC1HDAC2HDAC6 | |
| Hydrochloric Acid SCHEMBL28076132 | 0.79 | PDCD1 (0.33) | KDM4EHDAC3HDAC1HDAC2HDAC6 | |
| Hydrochloric Acid SCHEMBL27608299 | 0.79 | PDCD1 (0.33) | KDM4EHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL27752025 | 0.78 | PDCD1 (0.32) | KDM4EHDAC3HDAC1HDAC2HDAC6 | |
| Ethoxycarbonyl Group SCHEMBL27602841 | 0.75 | SMN1; SMN2 (0.32) | KDM4EHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL30704808 | 0.72 | — | — | |
| SCHEMBL1920222 | 0.72 | — | — | |
| SCHEMBL570248 | 0.72 | — | — | |
| SCHEMBL403436 | 0.72 | — | — | |
| SCHEMBL31415045 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108299428-B | 8- amido -7- methyl formate-pyrazine a pair of horses going side by side Pyridione derivatives and the preparation method and application thereof | 山东大学 | 2019-09-27 | — | — | CN | claimed |
| CN-101146540-A | HIV integrase inhibitors | MERCK & CO INC (US) | 2008-03-19 | — | — | CN | claimed |
| CN-110506039-A | Compounds and methods for targeted degradation of androgen receptor | ARVINAS INC | 2019-11-26 | — | — | CN | disclosed |
| CN-110494434-A | Pyrazolo chlorobenzene based compound, its composition and its application method | HOFFMANN LA ROCHE | 2019-11-22 | — | — | CN | disclosed |
| CN-108299428-B | 8- amido -7- methyl formate-pyrazine a pair of horses going side by side Pyridione derivatives and the preparation method and application thereof | 山东大学 | 2019-09-27 | — | — | CN | disclosed |
| CN-110214141-A | Benzodiazole compound as ENaC inhibitor | 企业治疗学有限公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-109983001-A | 2, 5-disubstituted 3-methylpyrazine and 2,5, 6-trisubstituted 3-methylpyrazine as allosteric SHP2 inhibitors | 锐新医药公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-109963843-A | Carbamoyloxymethyltriazolylcyclohexanes as LPA antagonists | 百时美施贵宝公司 | 2019-07-02 | — | — | CN | disclosed |
| CN-109923113-A | novel isoxazolyl ether derivatives as GABA A α 5 PAM | 豪夫迈·罗氏有限公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-104926801-B | Substituted azetidine analog derivative, the pharmaceutical composition containing it and its application in antitumor | 浙江大学 | 2019-06-04 | — | — | CN | disclosed |
| CN-109641885-A | Heterocyclic compound as immunomodulator | 因赛特公司 | 2019-04-16 | — | — | CN | disclosed |
| EP-1323726-A1 | ERYTHROMYCIN DERIVATIVES AND MEDICINES CONTAINING THE SAME | HOKURIKU SEIYAKU CO., LTD. (JP) | 2003-07-02 | — | — | EP | disclosed |
| EP-0748801-B1 | 2-ISOXAZOLINE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING RELATED DERIVATIVES FROM THE SAME | DAICEL CHEM (JP) | 2001-12-19 | — | — | EP | disclosed |
| US-6018069-A | 2-isoxazoline derivative and process for producing the same and process for producing related derivatives from the same | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2000-01-25 | — | — | US | disclosed |
| US-5994558-A | 2-isoxazoline derivative and process for producing the same; and process for producing related derivatives from the same | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1999-11-30 | — | — | US | disclosed |
| US-5962692-A | 2-isoxazoline derivative and process for producing the same, and process for producing related derivatives from the same | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5750717-A | 2-isoxazoline derivative and process for producing the same, and process for producing related derivatives from the same | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-12 | — | — | US | disclosed |
| EP-0748801-A1 | 2-ISOXAZOLINE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING RELATED DERIVATIVES FROM THE SAME | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-18 | — | — | EP | disclosed |
| EP-0488301-A1 | New benzopyran compounds with pharmacological activity | J. URIACH & CIA. S.A. (ES) | 1992-06-03 | — | — | EP | disclosed |
| US-4857351-A | PARTIAL ROASTING THEN SOAKING IN BASE OR COFFEE SOLIDS | THE PROCTER & GAMBLE COMPANY (US) | 1989-08-15 | — | — | US | disclosed |