Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592529 | 0.96 | — | — | |
| SCHEMBL6356002 | 0.82 | — | — | |
| Piperazine SCHEMBL3888557 | 0.82 | HIF1A (0.33) | — | |
| SCHEMBL2360350 | 0.78 | — | — | |
| SCHEMBL1829972 | 0.75 | — | — | |
| SCHEMBL27859696 | 0.74 | — | — | |
| SCHEMBL122361 | 0.74 | — | — | |
| SCHEMBL121600 | 0.74 | — | — | |
| Bromide SCHEMBL17434706 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL6193526 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110059981-A9 | New Pyridine Analogues V | ASTRAZENECA AB (SE) | 2011-03-10 | — | — | US | disclosed |
| US-20100137277-A1 | PYRIDINE COMPOUNDS AND THEIR USE AS P2Y12 ANTAGONISTS | ASTRAZENECA AB (SE) | 2010-06-03 | — | — | US | disclosed |
| US-20100069350-A1 | New Pyridine Analogues III | ASTRAZENECA AB (SE) | 2010-03-18 | — | — | US | disclosed |
| WO-2010005384-A1 | KETONE PYRIDINE ANALOGUES AND THEIR USE IN THE TREATMENT OF CARDIOVASCULAR DISORDERS | ASTRAZENECA AB (SE) | 2010-01-14 | — | — | WO | disclosed |
| WO-2010005385-A1 | 2-AMINO-6-ALKYL SUBSTITUTED PYRIDINE DERIVATIVES USEFUL AS P2Y12 INHIBITORS 308 | ASTRAZENECA AB (SE) | 2010-01-14 | — | — | WO | disclosed |
| US-20090318464-A1 | New Pyridine Analogues V | ASTRAZENECA AB (SE) | 2009-12-24 | — | — | US | disclosed |
| US-20090312368-A1 | Pyridine Analogues IV | ASTRAZENECA AB (SE) | 2009-12-17 | — | — | US | disclosed |
| US-20090227555-A2 | Novel Pyridine Compounds | ASTRAZENECA AB (SE) | 2009-09-10 | — | — | US | disclosed |
| CN-101511815-A | New pyridine analogues | ASTRAZENECA AB (SE) | 2009-08-19 | — | — | CN | disclosed |
| CN-101506193-A | New pyridine analogues | ASTRAZENECA AB (SE) | 2009-08-12 | — | — | CN | disclosed |
| US-20080032992-A1 | New Pyridine Analogues V | ASTRAZENECA AB (SE) | 2008-02-07 | — | — | US | disclosed |
| WO-2008004941-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |
| WO-2008004946-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |
| US-20080009523-A1 | New Pyridine Analogues IV | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | US | disclosed |
| WO-2008004942-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |
| WO-2008002247-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | disclosed |
| US-20070244088-A1 | New Pyridine Analogues II | ASTRAZENECA AB (SE) | 2007-10-18 | — | — | US | disclosed |
| EP-1836189-A1 | NOVEL PYRIDINE COMPOUNDS | AstraZeneca AB (SE) | 2007-09-26 | — | — | EP | disclosed |
| WO-2007008140-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |
| WO-2006073361-A1 | NOVEL PYRIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |