Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284125 | 1.00 | HRH3 (0.32) | HRH3MEN1KMT2AATM | |
| SCHEMBL376525 | 0.87 | HRH3 (0.34) | HRH3 | |
| SCHEMBL31217398 | 0.87 | HRH3 (0.34) | HRH3ATM | |
| SCHEMBL15203580 | 0.83 | GAA (0.32) | HRH3MEN1KMT2A | |
| SCHEMBL4276912 | 0.83 | HRH3 (0.31) | HRH3 | |
| SCHEMBL4282805 | 0.81 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL3237030 | 0.81 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL21110990 | 0.81 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL376846 | 0.81 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL21110961 | 0.80 | MEN1 (0.32) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518952-B2 | 6 substituted 2-heterocyclylamino pyrazine compounds as CHK-1 inhibitors | PFIZER INC. (US) | 2013-08-27 | — | — | US | disclosed |
| WO-2010016005-A1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER INC. (US) | 2010-02-11 | — | — | WO | disclosed |