Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.52 |
| ▸ | KIT | P10721 | 4/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL324291 | 0.88 | KIT (0.56) | JAK3KITAKT1ENPP1JAK2 | |
| SCHEMBL323131 | 0.86 | JAK3 (0.51) | JAK3KITAKT1ENPP1JAK2 | |
| SCHEMBL323306 | 0.83 | JAK3 (0.49) | JAK3KITAKT1ENPP1JAK2 | |
| SCHEMBL323917 | 0.82 | JAK3 (0.48) | JAK3KITAKT1ENPP1JAK2 | |
| SCHEMBL324107 | 0.82 | JAK3 (0.48) | JAK3KITAKT1JAK2JAK1 | |
| SCHEMBL323181 | 0.81 | KIT (0.64) | JAK3KITAKT1JAK2JAK1 | |
| SCHEMBL327154 | 0.81 | JAK3 (0.54) | JAK3KITAKT1JAK2JAK1 | |
| SCHEMBL323196 | 0.81 | KIT (0.58) | JAK3KITAKT1ENPP1JAK2 | |
| SCHEMBL323051 | 0.81 | KIT (0.56) | JAK3KITAKT1JAK2JAK1 | |
| SCHEMBL323644 | 0.81 | KIT (0.60) | JAK3KITAKT1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590981-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | Leo Pharma A/S (DK) | 2013-05-15 | — | — | EP | claimed |
| WO-2012003829-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-01-12 | — | — | WO | claimed |
| EP-2590981-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | Leo Pharma A/S (DK) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012003829-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-01-12 | — | — | WO | disclosed |