Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 16/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL606339 | 1.00 | HRH4 (0.54) | HRH4HRH3HTR3AROCK1 | |
| SCHEMBL606064 | 0.88 | HRH4 (0.58) | HRH4HRH3HTR3AROCK1 | |
| SCHEMBL12853426 | 0.88 | HRH4 (0.58) | HRH4HRH3HTR3AROCK1 | |
| SCHEMBL606513 | 0.85 | HRH4 (0.56) | HRH4HRH3HTR3AROCK1 | |
| SCHEMBL12853421 | 0.82 | HRH4 (0.60) | HRH4HRH3 | |
| SCHEMBL12853443 | 0.82 | HRH3 (0.65) | HRH4HRH3HTR3A | |
| SCHEMBL18550565 | 0.80 | HRH4 (0.64) | HRH4HRH3HTR3AROCK1 | |
| SCHEMBL18550564 | 0.80 | HRH4 (0.64) | HRH4HRH3HTR3AROCK1 | |
| SCHEMBL606357 | 0.80 | HRH4 (0.64) | HRH4HRH3HTR3AROCK1 | |
| SCHEMBL604782 | 0.80 | HRH4 (0.64) | HRH4HRH3HTR3AROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209775-A1 | HETEROBICYCLIC COMPOUNDS AS HISTAMINE H4-RECEPTOR ANTAGONISTS | UCB Pharma, S.A. (BE) | 2010-07-28 | — | — | EP | claimed |
| WO-2009047255-A1 | HETEROBICYCLIC COMPOUNDS AS HISTAMINE H4-RECEPTOR ANTAGONISTS | UCB PHARMA, S.A. (BE) | 2009-04-16 | — | — | WO | claimed |
| EP-2209775-A1 | HETEROBICYCLIC COMPOUNDS AS HISTAMINE H4-RECEPTOR ANTAGONISTS | UCB Pharma, S.A. (BE) | 2010-07-28 | — | — | EP | disclosed |
| WO-2010072829-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2010-07-01 | — | — | WO | disclosed |
| WO-2009047255-A1 | HETEROBICYCLIC COMPOUNDS AS HISTAMINE H4-RECEPTOR ANTAGONISTS | UCB PHARMA, S.A. (BE) | 2009-04-16 | — | — | WO | disclosed |